Detail of "6506-37-2"

Reference

The sensitivity of anaerobic gram-negative bacilli to four nitroimidazole derivatives

The sensitivity of anaerobic gram-negative bacilli to four nitroimidazole derivatives. Garcia Rodriguez, J. A.; Garcia Sanchez, J. E.; Saenz Gonzalez, M. C.; Prieto Prieto, J. (Fac. Med., Univ. Salamanca, Salamanca, Spain). Pharmatherapeutica, 1(9), 573-82 (English) 1977. CODEN: PHARDW. ISSN: 0308-051X. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Metronidazole (I) [443-48-1], tinidazole [19387-91-8], and ornidazole [16773-42-5] were good inhibitors of clin. isolates of Bacteroides and Fusobacterium, but nimorazole [6506-37-2] was less effective. The first 3 nitroimidazole derivs. inhibited 95% of the isolates at concns. of 6.25 mg/mL (readily attainable in blood), but nimorazole was effective against only 78% of the strains at this concn. Min. bactericidal concns. and min. inhibitory concns. were similar for these drugs, esp. ornidazole. With I, tinidazole, and ornidazole, the min. inhibitory concns. by agar diln. correlated well with the activities by the disk-diffusion method.

Micronucleus induction in mouse bone marrow cells of some nitrofuran, 5-nitroimidazole and nitrothiazole derivatives used as trichomonacides in Korea

Micronucleus induction in mouse bone marrow cells of some nitrofuran, 5-nitroimidazole and nitrothiazole derivatives used as trichomonacides in Korea. Paik, Sang Gi (Biotechnol. Dep., Lucky Cent. Res. Inst., Daejeon 300-31, S. Korea). Environ. Mutagens Carcinog., 5(2), 61-72 (English) 1985. CODEN: EMCAE8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In vivo cytogenetic effects of the title compds. on mouse bone marrow were studied by micronucleus test. Acute mouse toxicity test by oral administration showed that tinidazole [19387-91-8] and furazolidone [67-45-8] were almost non-toxic, metronidazole [443-48-1] and nimorazole [6506-37-2] were moderately toxic, whereas ornidazole [16773-42-5], aminitrozole [140-40-9], nifuratel [4936-47-4], atrican [3810-35-3] were extremely toxic. Bone marrow depression was obsd. in almost all trichomonacides except atrican. Nimorazole, metronidazole, and aminitrozole strongly induced micronuclei, while tinidazole and furazolidone exhibited slight induction. Ornidazole, nifuratel and atrican showed neg. results. Both oral and i.p. treatments with metronidazole on aq. soln. induced a dose-dependent increase in the incidence of micronuclei.In this experiment, several chemicals are used like 16773-42-5 and 19387-91-8 However, there was no increase in the incidence of micronuclei after i.p. treatment with metronidazole in CMC suspension. .