Reference

Preparation of cyclic amino alcohols from cyclic aminocarboxylic acids

Preparation of cyclic amino alcohols from cyclic aminocarboxylic acids. Tamura, Koji; Inoue, Kenichi (Mitsubishi Rayon Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2004026762 A2 29 Jan 2004, 9 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D207-08. ICS: C07D211-22; C07B053-00; C07M007-00. APPLICATION: JP 2002-188344 27 Jun 2002. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Cyclic amino alcs. I (R = CH2OH; m = 0-2; n = 2-4), useful as intermediates for antiamnesic agents, etc., are prepd. by treatment of cyclic aminocarboxylic acids I (R = CO2H; m, n = same as above) with Na bis(2-methoxyethoxy)aluminum hydride (II), followed by treatment of the reaction mixts.Several substances with their cas registry numbers 41373-39-1 and 68832-13-3 may be metioned in this study. with aq. solns. of org. acid alkali metal salts. Thus, (S)-proline was hydrogenated with II in THF at 50° for 3 h, treated with aq. Na K tartrate at 20-35°, the aq. phase removed, and the org. phase evapd. to give 85.0% (S)-prolinol with 82.0% purity. .

Asymmetric synthesis of (R)- and (S)-2-pyrrolidinemethanesulfonic acid

Asymmetric synthesis of (R)- and (S)-2-pyrrolidinemethanesulfonic acid. Braghiroli, Daniela; Avallone, Rossella; Di Bella, Maria (Dipartimento di Scienze Farmaceutiche, University of Modena, Modena 41100, Italy). 68832-13-3 are also occured in this study.Several substances are used for example 68832-13-3 which is its cas registry number. Tetrahedron: Asymmetry, 8(13), 2209-2213 (English) 1997 Elsevier. CODEN: TASYE3. ISSN: 0957-4166. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) (R)- and (S)-2-Pyrrolidinemethanesulfonic acid were synthesized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine. This asym. synthesis proceeds in mild conditions, with good overall yields and high enantiomeric purities (>99% ee). ..