Reference

Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart

Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart. Godfraind, T.; Saleh, M. Marwan (Lab. Pharmacodyn. Gen. Pharmacol., Univ. Cathol. Louvain, Brussels B-1200, Belg.). Arzneim.-Forsch., 34(9), 968-72 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of Aplodan (creatinol-o-phosphate) [6903-79-3] pretreatment was studied on the recovery of contractility of rat isolated heart after hypoxia or ischemia. In normoxia creatinol-O-phosphate (100 mmol/L) evoked a pos. inotropic effect only when glucose [50-99-7] was present in the physiol. soln., it also evoked a slight neg. chronotropic effect that was independent of glucose. When creatinol-O-phosphate was present during hypoxia, in the physiol. soln., the recovery of the contraction after reoxygenation (in the absence of the drug) was improved in a dose-dependent manner. When creatinol-O-phosphate was present in the physiol. soln. before ischemia, the recovery of the contractility after reperfusion was higher than in controls; the presence of creatinol-O-phosphate during reperfusion after ischemia accelerated the recovery of contractility. The action of creatinol-O-phosphate on the recovery of cardiac contractility after ischemia was also obsd. in hearts partially protected with a cardioplegic soln. Creatinol-O-phosphate could exert its cardioprotective effect by an action on anaerobic glycolysis.

Method of increasing intracellular concentrations of phosphate and increasing muscular contraction force

All Rights Reserved. Method of increasing intracellular concentrations of phosphate and increasing muscular contraction force. Peters, Jason R.; Chaudhuri, Shan; Ramsbottom, James D. (Aplodan Formulations Ltd., Can.). Can. Pat. Appl. CA 2556536 A1 19 Nov 2006, 15pp. (English). (Canada). CODEN: CPXXEB. APPLICATION: CA 2006-2556536 30 Aug 2006. 6903-79-3 and 56-65-5 which are cas registry numbers of substances are two of reagents here. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The invention relates to a method of increasing the intracellular concn. of phosphate by employing 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid as vehicle and method to transport phosphate into the cell. The increase in intracellular phosphate increases the availability of ATP and phosphocreatine, thereby leading to an increase in the anaerobic energy supply resulting in longer endurance and more forceful muscular contractions. .