Detail of "7008-42-6"

CAS Number:
7008-42-6
Name:
7H-Pyrano[2,3-c]acridin-7-one,3,12-dihydro-6-methoxy-3,3,12-trimethyl-
Molecular Structure:
Formula:
C20H19 N O3
Molecular Weight:
321.40
Synonyms:
Acromycine;Acronin; Acronine; Acronycin; Acronycine; Compound 42339; NCI-C 01536; NSC 403169
Safety:
Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine: Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine. Bourne, D. W. A.; Higuchi, T.; Repta, A. J. (Victorian Coll. Pharm., Melbourne, Aust.). J. Pharm. 63842-46-6 is the cas registry number of certain chemical which is used as reagents here. Sci., 66(5), 628-31 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 31 The low aq. soly. of acronine (I) [7008-42-6] (.apprx.2 mg/l) was overcome by identification of quaternary prodrug salts exhibiting apparent molar solubilities 2 to 5 orders of magnitude greater than I. The synthesis and kinetics of hydrolysis of the various prodrug acetylacroninium salts II (X = HClO4, Cl, sulfate phosphate and Br) were studied, and the half-life for hydrolysis under conditions approximating the in vivo situation was estd. to be about 5 min. Such rapid reversion, together with the greatly increased soly., appears to qualify the prodrug for i.v. use. .

Effects of acronycine, bleomycin and cytosine arabinoside on the cell cycle: Effects of acronycine, bleomycin and cytosine arabinoside on the cell cycle. Some aspects of their interaction with radiation determined by pulse cytophotometry. Reddy, S. B.; Linden, W. A.; Zywietz, F.; Baisch, H.; Struck, U. (Inst. Biophys. Radiobiol., Univ. Hamburg, Hamburg, Ger.). Arzneim.-Forsch., 27(8), 1549-53 (English) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 Acronycine (I) [7008-42-6] (10 .mu.g/mL) or bleomycin [11056-06-7] (100 .mu.g/mL) caused accumulation of mouse fibroblasts (L-cells) in the G2 plus M phases of the cell cycle, and the effect was enhanced by pretreatment with x-rays. Cytosine arabinoside (II) [147-94-4] (0.2 .mu.g/mL) reversibly blocked cells in the S-phase, and this effect was decreased by x-rays. The results are discussed in relation to cell-cycle-specific radiation therapy.