Reference

Water soluble lipopolymers for interleukin-12 gene delivery

Water soluble lipopolymers for interleukin-12 gene delivery. Mahato, R. I.; Lee, M.; Han, S.-O.; Maheshwari, A.; Furgeson, D. Y.; Kim, S. W. (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112-5820, USA). Proceedings - 28th International Symposium on Controlled Release of Bioactive Materials and 4th Consumer & Diversified Products Conference, San Diego, CA, United States, June 23-27, 2001, Volume 2, 1219-1220. Controlled Release Society: Minneapolis, Minn. (English) 2001. CODEN: 69CNY8. DOCUMENT TYPE: Conference CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 3 A water-sol. lipopolymer prepd. by using cholesteryl chloroformate and polyethylenimine (PEI) of 1800 Da was evaluated for interleukin-12 (IL-12) gene delivery to cultured tumor cells and tumor-bearing mice.In this experiment, several chemicals are used like 9002-98-6 and 7144-08-3 In addn., IL-12 expression plasmid constructed using two independent promoters for p35 and p40 subunits was also evaluated. .

Synthesis of amphiphilic hydroxyl terminated poly(amidoamine) dendrimer

All Rights Reserved. Synthesis of amphiphilic hydroxyl terminated poly(amidoamine) dendrimer. Zhang, Donghui; Hamilton, Paul D.; Kao, Jeff L.Chemicals with cas numbers 26937-01-9 and 7144-08-3 also play role.-F.; Ravi, Nathan ( Department of Veterans Affairs Medical Center, St Louis, MO 63106, USA). Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47(1), 321-322 (English) 2006 American Chemical Society, Division of Polymer Chemistry. CODEN: ACPPAY. ISSN: 0032-3934. DOCUMENT TYPE: Journal; (computer optical disk) CA Section: 35 (Chemistry of Synthetic High Polymers) Amphiphilic poly(amidoamine) G5 dendrimers partially hydrophobized by either dodecyl or cholesteryl groups were synthesized by a one-step chloroformate conjugation with hydroxyl termini of dendrimer and analyzed using 1H NMR and Reverse-Phase HPLC. Unlike the dodecyl chloroformate-poly(amidoamine) reaction, which exhibited a stoichiometric relationship, the reaction of cholesteryl chloroformate with dendrimer occurred in a lower than expected ratio. Both the dodecyl and cholesteryl derivs. were a mixt. of partially hydrophobilized dendrimers. Further purifn. by chromatog. should lead to amphiphilic dendrimers with a well-controlled degree of hydrophobicity. These materials are of interest in biomedical applications. .