Detail of "73671-92-8"

Reference

Preparation of 17b-(N-adamantylcarbamoyl)-4-aza-5a-androsten-3-ones and analogs as antiandrogenics

Preparation of 17b-(N-adamantylcarbamoyl)-4-aza-5a-androsten-3-ones and analogs as antiandrogenics. Steinberg, Nathan G.; Rasmusson, Gary H.; Salzmann, Thomas N. (Merck and Co., Inc., USA). Eur. Pat. Appl. EP 462662 A2 27 Dec 1991, 11 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI, NL. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07J073-00. 73671-92-8 and 139512-73-5 are cas registry numbers of chemicals which are used as reagents here. ICS: A61K031-56. APPLICATION: EP 91-201489 14 Jun 1991. PRIORITY: US 90-540968 20 Jun 1990. DOCUMENT TYPE: Patent CA Section: 32 (Steroids) Section cross-reference(s): 2 Title compds. (I; R = H, Me, Et; R2 = 1- or 2-adamantyl, 1- or 2- norbornyl; dashed line = optional bond) were prepd. as testosterone 5a-reductase inhibitors (no data). Thus, azaandrostane II (R = H, R1 = OMe, dashed line = null) was dehydrogenated to II (R = H, dashed line = bond) (III; R1 = OMe) which was condensed with 2-adamantanamine to give III (R1 = 2-adamantylamino). .

Preparation of 17b-aroyl-4-aza-5a-androst-1-en-3-ones as steroidal reductase inhibitors

Preparation of 17b-aroyl-4-aza-5a-androst-1-en-3-ones as steroidal reductase inhibitors. Steinberg, Nathan G.; Rasmusson, Gary H.; Salzmann, Thomas N. (Merck and Co., Inc., USA). Eur. Pat. Appl. EP 462665 A2 27 Dec 1991, 9 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI, NL. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07J073-00. 73671-92-8 and 103335-49-5 are cas registry numbers of chemicals which are used as reagents here. ICS: A61K031-56. APPLICATION: EP 91-201492 14 Jun 1991. PRIORITY: US 90-540967 20 Jun 1990. DOCUMENT TYPE: Patent CA Section: 32 (Steroids) Section cross-reference(s): 2 Title compds. [I; R = H, Me, Et; R2 = (substituted) polycyclic aryl; dashed line = optional bond] were prepd. as testosterone 5a-reductase inhibitors (no data). Thus, azaandrostane II (R = H, R2 = OMe, dashed line = null) was dehydrogenated to II (R = H, dashed line = bond) (III; R2 = OMe) which was condensed with 2,2'-dipyridyl disulfide to give III (R2 = 2-pyridylthio). The latter was condensed with the Grignard reagent from 4-bromobiphenyl to give III (R2 = 4-PhC6H4). .