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73684-69-2

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Basic Information

Molecular Structure:
CAS No.:	73684-69-2
Name:	miporamicin
Article Data:	2

Formula:	C37H61 N O13
Molecular Weight:	727.89
Synonyms:	MycinamicinI, 14-hydroxy-; 4,17-Dioxabicyclo[14.1.0]heptadecane, mycinamicin I deriv.;Antibiotic A 11725II; Antibiotic AR 5-2; Miporamicin; Mirosamicin; Mirosamycin;Mycinamicin II; Mycinomycin II
Density:	1.22g/cm³
Melting Point:	104°C
Boiling Point:	843.2°C at 760 mmHg
Flash Point:	463.7°C
Safety:	Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	175.21000
LogP:	1.76370

Synthetic route

: 122825-79-0
mycinamicin II 3'-N-oxide

: 73684-69-2
mycinamicin II

Conditions	Yield
With triphenylphosphine In dichloromethane at 55℃; for 67h;	56%

: mycinamicin-IV

A: C36H59NO11

B: mycinamicin-I

C: 73684-71-6
mycinamicin-III

D: 73684-72-7
mycinamicin V

E: 73684-69-2
mycinamicin II

Conditions	Yield
With multifunctional biosynthetic P450 monooxygenase; rhodococcus reductase domain; NADPH In aq. buffer at 28℃; for 2h; pH=7.3; Kinetics; Reagent/catalyst; Enzymatic reaction;	A 18.5% B n/a C n/a D n/a E n/a

: 73684-72-7
mycinamicin V

: 73684-69-2
mycinamicin II

Conditions	Yield
Multi-step reaction with 2 steps 1: 39 percent / MCPBA, disodium hydrogen phosphate / CH2Cl2 / 23 h / 60 °C 2: 56 percent / triphenylphosphine / CH2Cl2 / 67 h / 55 °C View Scheme

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73684-69-2
4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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The company is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds,
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4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production in China for chemicals cus
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73684-69-2
4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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73684-69-2
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Casno:
73684-69-2
4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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Hubei Jiutian Bio-medical Technology CO.,Ltd, which is professional in research and sale high techology.The company located in Wuhan, We insist on the concept of "technology first,
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73684-69-2
miporamicin
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factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica
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73684-69-2
4,17-Dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione,2-[[(6-deoxy-2,3-di-O-methyl-b-D-allopyranosyl)oxy]methyl]-3-ethyl-2-hydroxy-8,10,12-trimethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-he
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Chemistry

The IUPAC name of Mirosamicin (CAS NO.73684-69-2):
(1R,2S,3R,6E,8S,9S,10S,12R,14E,16R)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-8,10,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione
Synonyms: Miporamicin;A-11725II ; Antibiotic A-11725II ; Antibiotic AR-5-2 ; AR-5-2 ; Mycinamicin II
CAS: 73684-69-2
Molecular formula:C₃₇H₆₁NO₁₃
Molecular Structure:

Molecular Weight 727.87914 g/mol
Index of Refraction: 1.545
Density: 1.22 g/cm³
Flash Point: 463.7 °C
Boiling Point: 843.2 °C at 760 mmHg

Toxicity Data With Reference

The toxicity of Mirosamicin (CAS NO.73684-69-2):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD₅₀	intraperitoneal	363mg/kg (363mg/kg)		Journal of Antibiotics. Vol. 33, Pg. 364, 1980.
mouse	LD₅₀	oral	2gm/kg (2000mg/kg)		British UK Patent Application. Vol. #2020647A,
mouse	LD₅₀	subcutaneous	465mg/kg (465mg/kg)		Journal of Antibiotics. Vol. 33, Pg. 364, 1980.

Safety Profile

The safety information of Mirosamicin (CAS NO.73684-69-2):
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NO_x.

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