Detail of "7560-83-0"

Reference

Topical pharmaceuticals containing amine oxides

Topical pharmaceuticals containing amine oxides. Johnson, Dee L.Some chemicals with cas registry numbers like 120-94-5 and 7529-17-1 are also used.; Senta, Therese A.; Sirvio, Larry M. (Minnesota Mining and Mfg. Co. , USA). U.S. US 4411893 A 25 Oct 1983, 6 pp. Cont.-in-part of U.S. Ser. No. 292,809, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-71; A61K031-13. NCL: 424181000. APPLICATION: US 82-422891 24 Sep 1982. PRIORITY: US 80-187089 15 Sep 1980; US 81-292809 14 Aug 1981. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 23, 24, 27 Skin penetration of drugs in topical compns. may be enhanced by the addn. of amine oxides to the compn. The amine oxides show minimal toxic side effects as compared to DMSO. Thus, dicyclohexylmethylamine oxide (I) [88374-60-1] was prepd. by the oxidn. of diclohexylmethylamine [7560-83-0] with H2O2 in THF soln. Skin penetration of erythromycin [114-07-8] through hairless mouse skin was 20.2% when I was used as compared to 7.5% with EtOH-H2O (2:1) control. Topical formulations are tabulated. .

Polyfunctionalized nitrogen-containing surfactants

Polyfunctionalized nitrogen-containing surfactants. VII. Substitution and elimination in the reaction of 1,2-dihaloalkanes with amines. Beger, J.; Meerbote, E. (Sekt. Chem., Bergakad. Freiberg, Freiberg DDR-9200, Ger. Dem. Rep.). J. Prakt. Chem., 326(1), 12-22 (German) 1984. CODEN: JPCEAO. ISSN: 0021-8383. DOCUMENT TYPE: Journal CA Section: 46 (Surface Active Agents and Detergents) Section cross-reference(s): 23, 27, 28 Compds. RCHR1CH2R2 (R = Me or C6-13 alkyl, R1 = Cl or Br, R2 = Cl or Br) reacted with N,N-dicyclohexylmethanamine [7560-83-0] to give elimination products and reacted with primary and secondary amines, such as alkylamines, dialkylamines, and azacycloalkanes, to give both elimination and substitution products (often in nearly equal proportion). The elimination products were 1-halo-1-alkenes (cis and trans), 2-halo-1-alkenes, 1-alkenes, and 1,3- and 2,4-alkadienes. The main substitution products were 1,2-diaminoalkanes. The crit. micelle concns. 66291-72-3 and 89632-07-5 are just another two chemicals used in this study. were detd. for 8 1,2-diaminoalkane dihydrochlorides and 13 N-alkylazacycloalkane hydrochlorides. .