Detail of "75899-68-2"

Reference

DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells

DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells. Marinari, Umberto M.; Ferro, Margherita; Sciaba, Luigi; Finollo, Renata; Bassi, Anna Maria; Brambilla, Giovanni (Inst. Gen. Pathol., Univ. Genoa, Genoa, Italy). Cell Biochem. Funct., 2(4), 243-8 (English) 1984. CODEN: CBFUDH. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Alk. elution was employed to study DNA damage in CHO-Kl cells treated with a series of biotic and xenobiotic aldehydes. DNA cross-linking was measured in terms of the redn. in the effect of Me methanesulfonate on the kinetics of DNA elution and obsd. in cells treated with formaldehyde [50-00-0], acetaldehyde [75-07-0], methylglyoxal [78-98-8], and malonaldehyde [542-78-9]. Propionaldehyde [123-38-6], valeraldehyde [110-62-3], hexanal [66-25-1], and 4-hydroxynonenal [75899-68-2] produced DNA single-strand breaks, or lesions which were converted to breaks in alkali. Both types of DNA damage occurred in cells exposed to malealdehyde [3675-13-6]. These findings support the hypothesis of a carcinogenic effect of the aldehydic products (malonaldehyde, methylglyoxal, propionaldehyde, hexanal, 4-hydroxynonenal) released in biomembranes during lipid peroxidn.

Lipid peroxides and eicosanoid biosynthesis in platelets

Lipid peroxides and eicosanoid biosynthesis in platelets. Selley, M. L.; Ardlie, N. G. (Woden Valley Hosp., Australian Natl. Univ., Garran ACT 2605, Australia). Int. Congr. Ser. - Excerpta Med., 696(Atherosclerosis 7), 477-80 (English) 1986. CODEN: EXMDA4. ISSN: 0531-5131. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The addn. of 10-100 mM 4-hydroxynonenal [75899-68-2] to platelet-rich plasma from healthy human donors enhanced platelet aggregation and increased thromboxane B2 [54397-85-2] formation caused by ADP, thrombin, and ionophore A23187. The platelet responses to collagen, epinephrine, and arachidonic acid were not affected by the hydroxynonenal. Similar effects were obsd. with 4-hydroxydecenal [73529-64-3]. Concns. of hydroxynonenal >100 mM inhibited the platelet activation. Acrolein [107-02-8] (50-500 mM) also enhanced aggregation and thromboxane B2 formation by the platelets. However, in contrast to hydroxynonenal, acrolein potentiated the platelet activation caused by arachidonic acid and thrombin, but not by ADP, epinephrine, collagen, or A23187. The platelet aggregation was inhibited by concns. of >500 mM acrolein.