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| CAS No.: | 761404-85-7 |
|---|---|
| Name: | Trityl olMesartan acid |
| Article Data: | 12 |
| Molecular Structure: | |
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| Formula: | C43H40N6O3 |
| Molecular Weight: | 688.829 |
| Synonyms: | OMST-B |
| Density: | 1.22±0.1 g/cm3(Predicted) |
| Boiling Point: | 901.0±75.0 °C(Predicted) |
| PSA: | 118.95000 |
| LogP: | 7.97020 |
- 81281-59-67-Benzylideneaminotheophylline
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- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 144690-33-5
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With potassium hydroxide In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere; | 98.11% |
| Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate With potassium hydroxide In isopropyl alcohol at 60℃; for 4h; Stage #2: With hydrogenchloride In water | 90% |
| Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate With potassium hydroxide In water; isopropyl alcohol at 60℃; for 4h; Stage #2: With hydrogenchloride In water | 90% |
- 124750-51-2
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
- 144689-93-0
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
A
- 144690-33-5
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
B
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With potassium phosphate In N,N-dimethyl acetamide at 60 - 65℃; for 6h; Solvent; Reagent/catalyst; | A 89.6% B 0.02% C 0.02% |
- 124750-51-2
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl acetamide; acetone / 10 h / Reflux 2: potassium hydroxide / water; isopropyl alcohol / 4 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: potassium carbonate / acetone; N,N-dimethyl acetamide / 10 h / Reflux 2: potassium hydroxide / isopropyl alcohol / 4 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: lithium hydroxide / acetonitrile / 5 h / 70 - 75 °C / Autoclave 2: potassium hydroxide; water / 30 - 45 °C View Scheme |
- 144689-93-0
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl acetamide; acetone / 10 h / Reflux 2: potassium hydroxide / water; isopropyl alcohol / 4 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: potassium carbonate / acetone; N,N-dimethyl acetamide / 10 h / Reflux 2: potassium hydroxide / isopropyl alcohol / 4 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1: lithium hydroxide / acetonitrile / 5 h / 70 - 75 °C / Autoclave 2: potassium hydroxide; water / 30 - 45 °C View Scheme |
- 76-83-5
trityl chloride
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
| With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; acetone at 48 - 52℃; for 2h; Product distribution / selectivity; |
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
- 1304676-48-9
(1-adamantyl)carbonyloxymethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(1-trityltetrazol-5-yl)phenyl]phenylmethyl}imidazole-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: (1-adamantyl)carbonyloxymethyl halide In N,N-dimethyl acetamide at 70℃; for 2h; | 95.4% |
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
- 99464-83-2
1-chloroethyl cyclohexyl carbonate
- 1337980-10-5
1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
| Conditions | Yield |
|---|---|
| With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 70℃; for 2h; | 95% |
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
- 80841-78-7
4-chloromethyl-5-methyl-1,3-dioxol-2-one
- 144690-92-6
trityl olmesartan medoxomil
| Conditions | Yield |
|---|---|
| With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 0 - 45℃; for 3h; Inert atmosphere; | 94% |
| Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid With potassium carbonate In N,N-dimethyl-formamide at 20℃; Autoclave; Stage #2: 4-chloromethyl-5-methyl-1,3-dioxol-2-one With potassium iodide In N,N-dimethyl-formamide at 20℃; | 91.6% |
| With potassium carbonate; potassium iodide In acetone Product distribution / selectivity; Reflux; | |
| In water; acetone at 48 - 52℃; for 5h; Product distribution / selectivity; | |
| With potassium bromide In N,N-dimethyl acetamide at 15 - 50℃; for 8.6h; Time; Green chemistry; | 23.2 g |
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
- 1301629-88-8
[1-(benzoyloxy)]ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(1-trityltetrazol-5-yl)phenyl]phenylmethyl}imidazole-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: [1-(benzoyloxy)]ethyl halide In N,N-dimethyl acetamide at 70℃; for 2h; | 88.9% |
- 761404-85-7
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
- 1304689-26-6
[1-(cyclohexylcarbonyloxy)]ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(1-trityltetrazol-5-yl)phenyl]phenylmethyl}imidazole-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid With potassium carbonate; potassium iodide In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: [1-(cyclohexylcarbonyloxy)]ethyl halide In N,N-dimethyl acetamide at 70℃; for 2h; | 88.2% |
