Reference

Aztreonam concentrations in human prostatic tissue

Aztreonam concentrations in human prostatic tissue. Madsen, P. O.; Dhruv, R.; Friedhoff, L. T. (Sch. Med., Univ. Wisconsin, Madison, WI 53705, USA). Antimicrob. Agents Chemother., 26(1), 20-1 (English) 1984. CODEN: AMACCQ. ISSN: 0066-4804. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The concns. of aztreonam (I) [78110-38-0] in human prostatic tissue specimens obtained by transurethral resection were measured in patients after the i.m. administration of a single 1-g dose. The av. concn. of aztreonam was 7.8 mg/g of prostate between 50 and 180 min after dosage. The av. ratio of the drug concn. in prostate to that in serum was 0.25. The concns. of aztreonam achieved were significantly higher than the MICs (min inhibitory concns.) for most members of the family Enterobacteriaceae implicated in chronic prostatitis.

Ototoxicity of subcutaneously administered aztreonam in neonatal rats

Ototoxicity of subcutaneously administered aztreonam in neonatal rats. Myhre, John L.; DePaoli, Alexander; Keim, G. Richard (Dep. Pathol., Squibb Inst. Med. Res., New Brunswick, NJ 08903, USA). Toxicol. Appl. Pharmacol., 77(1), 108-15 (English) 1985. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Aztreonam (SQ 26,776) (I) [78110-38-0] was given s.c. to neonatal rats at daily doses of 150, 600, and 2400 mg/kg on postnatal days 10-16. Similar groups given 400 mg streptomycin/kg/day or 0.9% NaCl on the same schedule served as a pos. and neg. control group, resp. On postnatal days 28 and 56, the neonates were evaluated for level of spontaneous activity and auditory and vestibular function. Half of the neonates in each group were necropsied on postnatal day 29, and the other half on postnatal day 57. The inner ears of all neonates were evaluated for histopathol. evidence of ototoxicity. No functional or histopathol. evidence of ototoxicity was found in any neonatal rat dosed with aztreonam or saline. However, neonates given streptomycin were hyperactive, had severely impaired hearing and vestibular function, and had morphol. changes in the sensory nerve endings of the semicircular canals, utriculus, saculus, and cochlea. The histopathol. evidence of the ototoxic effects of streptomycin correlated highly with the functional data. Thus, under these conditions, aztreonam demonstrated no ototoxic effects in neonatal rats.