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79617-96-2

CAS Number:
79617-96-2
Name:
1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-
Superlist Name:
Sertraline
Molecular Structure:
Formula:
C₁₇H₁₇Cl₂N
Molecular Weight:
342.73
Synonyms:
1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S-cis)-;(+)-Sertraline;(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine;CP 51974;
Density:
1.25 g/cm³
Boiling Point:
416.3 °C at 760 mmHg
Flash Point:
205.6 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

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CAS No.79617-96-2 Sertraline

DetailDesc:Sertraline

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Reference

Sertraline: a new selective inhibitor of serotonin uptake: Sertraline: a new selective inhibitor of serotonin uptake. Koe, B. Kenneth; Weissman, Albert; Welch, Willard M.; Browne, Ronald G. (Cent. Res. Div., Pfizer Inc., Groton, CT 06340, USA). Psychopharmacol. Bull., 19(4), 687-91 (English) 1983. CODEN: PSYBB9. ISSN: 0048-5764. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacol. activity of sertraline (I) [79617-96-2] was evaluated in tests predictive of 5-HT [50-67-9] uptake inhibiting and antidepressant activity. I is a highly selective and potent inhibitor of synaptosomal 5-HT uptake in rat brain. N-Demethylsertraline [87857-41-8], the major metabolite of I, is also a selective 5-HT uptake blocker, indicating that this selective inhibition is probably maintained in vivo.There are some commonly used reagents with their cas registry numbers 50-67-9 and 87857-41-8 in this article. I markedly reduced the immobility of mice in the Porsolt forced swimming test; in addn. repeated dosing of I induced down regulation of norepinephrine coupled adenylate cyclase in rat limbic forebrain. Thus, I should be clin. effective as an antideppressant. .

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression: Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. Kennett, G. A.; Dourish, C. T.; Curzon, G. (Dep. Neurochem., Inst. Neurol., London WC1N 3BG, UK). Eur. J. Pharmacol., 134(3), 265-74 (English) 1987. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Previous results have suggested that behavioral adaptation to restraint might be promoted by postrestraint stimulation of 5-HT1A receptors. Therefore, rats were restrained for 2 h and injected with vehicle or 60-1000 mg/kg of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) [78950-78-4] s. 78950-78-4 and 129-03-3 which are cas registry numbers of chemicals are mentioned.c. Vehicle treated restrained rats showed reduced locomotor activity and increased defecation in an open-field test the day after the end of restraint. A single injection of 250 or 1000 mg/kg 8-OH-DPAT attenuated these effects. The above locomotor deficits were also attenuated by chronic pretreatment with the antidepressants desipramine [50-47-5] and sertraline [79617-96-2] but not by a single treatment with desipramine or the benzodiazepine anxiolytic drugs chlordiazepoxide [58-25-3] and diazepam [439-14-5]; none of these treatments unambiguously reversed stress-induced increases in defecation. Evidence suggests that the above action of 8-OH-DPAT is mediated by 5-HT1A receptors since it was antagonized by the 5-HT1A antagonist spiperone but not by the 5-HT2 antagonist ketanserin and was not mimicked by the 5-HT1B agonist RU 24969. However, the 5-HT1A agonists buspirone [36505-84-7] and TVXQ 7821 (ipsapirone) [92589-98-5] and the nonspecific 5-HT agonist quipazine [4774-24-7] all possess similar properties to 8-OH-DPAT in this test. The results suggest that 5-HT1A agonists may have rapid antidepressant properties. .

79617-96-2

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-

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CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-

CAS No.79617-96-2 1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

CAS No.79617-96-2 Sertraline

Reference