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Parenteral treatment of clinical mastitis with tylosin base or penethamate hydriodide in dairy cattle

All Rights Reserved. Parenteral treatment of clinical mastitis with tylosin base or penethamate hydriodide in dairy cattle. McDougall, S.; Agnew, K. E.; Cursons, R.; Hou, X. X.; Compton, C. R.In this study， 808-71-9 and 1405-53-4 are also used. W. (Animal Health Centre, Morrinsville, N. Z.). Journal of Dairy Science, 90(2), 779-789 (English) 2007 American Dairy Science Association. CODEN: JDSCAE. ISSN: 0022-0302. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 The objective of this study was to compare the clin. and bacteriol. cure rates of cows with clin. mastitis following treatment with either tylosin base (5 g injected 3 times at 24-h intervals; n = 306) or penethamate hydriodide (5 g injected 3 times at 24-h intervals; n = 289). Duplicate milk samples were collected before treatment and again 14 ± 3 and 21 ± 3 d later for microbiol. anal. Only those quarters from which gram-pos. mastitis pathogens were isolated before treatment were included in the analyses. Streptococcus uberis was the most prevalent isolate. The no. of cows with clin. failure (i.e., retreated within 21 d of enrollment) did not differ between treatments (64 vs. 63, resp.). At the quarter level, there was no difference in the proportion of bacteriol. cure between treatments (81.2 vs. 83.8% for penethamate hydriodide or tylosin, resp.). The proportions of clin. and bacteriol. cure were influenced by age, herd, severity of mastitis, no. of glands within the cow with clin. mastitis, bacterial species, and days postpartum at enrollment. There was no difference between treatment groups for SCC (4.46 vs. 4.44 ± 0.08, mean ± std. error of the difference in ln SCC for cows treated with penethamate hydriodide or tylosin, resp.) or prodn. of milk solids (1.45 vs. 1.48 ± 0.02 kg/d of milk fat + protein, for the penethamate hydriodide or tylosin treatment, resp.). Overall, there was no difference in the proportions of clin. failure (17.3 vs. 16.5% of cows treated with penethamate hydriodide or tylosin, resp.) or bacteriol. cure (79.8 vs. 82.0% of cows treated with penethamate hydriodide or tylosin, resp.), or in SCC or milk prodn. between dairy cows with clin. mastitis and those treated for clin. mastitis with 1 of 2 parenteral antibiotic therapies. .