808-71-9

Basic information

• Product Name: diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide
• Synonyms: diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide;4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(phenylacetyl)amino- (2S,5R,6R)-, 2-(diethylamino)ethyl ester, monohydriodide;Penethamate·hydroiodic acid;penethamate hydriodide;(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-(diethylamino)ethyl ester hydriodide;Penethacillin hydriodide;Penicillin G 2-(diethylamino)ethyl ester hydriodide;Benzylpenicillin Diethylaminoethyl Ester Hydroiodide
• CAS NO: 808-71-9
• Molecular Formula: C₂₂H₃₁N₃O₄S*HI
• Molecular Weight: 561.47665
• EINECS: 212-367-6
• Mol File: 808-71-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 178-179℃
• Boiling Point: 644.1 °C at 760 mmHg
• Flash Point: 343.3 °C
• Appearance: /
• Vapor Pressure: 1.76E-16mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide(808-71-9)
• EPA Substance Registry System: diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide(808-71-9)

Safety Data

• Hazardous Substances Data: 808-71-9(Hazardous Substances Data)

Usage

Uses

Benzylpenicillin Diethylaminoethyl Ester Hydroiodide is a prodrug of Benzylpenicillin. It is an antimicrobial/antibacterial agent that is used primarily in the treatment of bovine mastitis.

InChI:InChI=1/C22H31N3O4S.HI/c1-5-24(6-2)12-13-29-21(28)18-22(3,4)30-20-17(19(27)25(18)20)23-16(26)14-15-10-8-7-9-11-15;/h7-11,17-18,20H,5-6,12-14H2,1-4H3,(H,23,26);1H/t17-,18+,20-;/m1./s1

Upstream product

• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 113-98-4 Penicillin G potassium 
• 3689-73-4 penethacillin 
• 69-57-8 Penicillin G sodium 
• 100410-46-6 [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabiscyclo[3,2,0]heptane-2-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride 

Relevant articles and documents

Improved preparation method of penicillin hydriodate

The invention relates to the field of pharmacy, and particularly provides an improved preparation method of penicillin hydriodate, which comprises the following steps: 1) dissolving penicillin citrate with water, then adding a sodium iodide or potassium iodide solution for reaction, growing crystals, filtering, washing and drying to obtain the penicillin hydriodate. The method disclosed by the invention has the advantages of high yield, easiness in operation and small toxicity, the reaction condition is mild, the product purification, intermediate storage and impurity control are facilitated, and the penicillin hydriodate product with good stability is obtained.

Synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide

Processes of synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide were studied. The optimal conditions of benzylpenicillin esterification with chloroethyldiethylamine in dimetylformamide and acetonitrile were found. Processes for isolation of the target product were developed and its physicochemical properties were studied. Product stabilization conditions providing a stable pH value in solutions of benzylpenicillin β-diethylaminoethyl ester hydroiodide were found.