Reference

Application of calcium thioglycolate to improve transdermal delivery of theophylline in rats

Application of calcium thioglycolate to improve transdermal delivery of theophylline in rats. Kushida, Kazuo; Masaki, Keiji; Matsumura, Masayoshi; Ohshima, Taeyuki; Yoshikawa, Hiroshi; Takada, Kanji; Muranishi, Shozo (Res. Lab., Teikoku Pharm.In this study， 9002-92-0 and 58-55-9 are also used. Co., Ltd., Ohuchi 769-26, Japan). Chem. Pharm. Bull., 32(1), 268-74 (English) 1984. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The effect of Ca thioglycollate (Ca-TGA) [814-71-1] on the percutaneous absorption of theophylline (I) [58-55-9] in comparison with the promoting effects of DMSO and Bl-9EX (polyoxyethylene lauryl ether) [9002-92-0] was studied. The I plasma concns. were detd. following skin application of aminophylline to male rats in vitro. The use of aq. 4 wt./vol.% Ca-TGA gave a plasma concn. 40-fold as high as that of the control, whereas 80 vol./vol.% DMSO and 20 wt./vol.% BL-9EX gave concns. 9-fold as high as that of the control at most. To obtain a marked promoting effect with Ca-TGA, a pretreatment time of >10 min was needed. When Ca-TGA was removed, the promoting effect gradually disappeared and the control value was reached at 48 h. Furthermore, when pretreatments with Ca-TGA and BL-9EX were combined, the transdermal delivery of I was promoted in comparison to the pretreatment with either of the compds. used singly. .

Corrosion-inhibited, high-density, liquid agent

Corrosion-inhibited, high-density, liquid agent. Handy, Russell F., Jr. (Great Lakes Chemical Corp., USA). Ger. Offen. DE 3316677 A1 8 Dec 1983, 29 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C09K007-02. APPLICATION: DE 83-3316677 6 May 1983. 10043-52-4 and 5421-46-5 are cas registry numbers of chemicals which are used as reagents here. PRIORITY: US 82-386281 8 Jun 1982. DOCUMENT TYPE: Patent CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Section cross-reference(s): 55 High-d. aq. drilling fluids based on ZnBr2, CaBr2, and CaCl2 contain up to 3.0 wt.% of a corrosion inhibitor selected from NH4 thioglycolate [5421-46-5], Ca thioglycolate [814-71-1], and thioglycerol [96-27-5]. The fluids show low corrosion rates under severe conditions. .