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CAS No.: | 964-21-6 |
---|---|
Name: | O6-METHYL-2'-DEOXYGUANOSINE |
Article Data: | 16 |
Molecular Structure: | |
Formula: | C11H15 N5 O4 |
Molecular Weight: | 281.271 |
Synonyms: | 9H-Purine,2-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methoxy- (8CI); 9H-Purine,2-amino-9-(2-deoxy-b-D-ribofuranosyl)-6-methoxy- (7CI); 2-Amino-6-methoxy-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine;2'-Deoxy-6-methylguanosine; 6-O-Methyl-2'-deoxyguanosine;6-O-Methyldeoxyguanosine; O6-Methyl-2'-deoxyguanosine; O6-Methyldeoxyguanosine |
Density: | 1.84 g/cm3 |
Boiling Point: | 674.7 °C at 760 mmHg |
Flash Point: | 361.9 °C |
PSA: | 128.54000 |
LogP: | -0.36100 |
2'-deoxy-N2-isobutyryl-O6-methylguanosine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
With ammonium hydroxide at 50℃; for 72h; | 100% |
With potassium hydroxide for 8h; Ambient temperature; | 99% |
With potassium hydroxide at 22℃; Rate constant; |
2-N-trifluoroacetamido-6-pentafluorophenoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine
sodium methylate
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
In methanol at 55℃; for 36h; | 85% |
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
With sodium methylate In methanol for 1h; | 76% |
sodium methylate
2-amino-6-chloro-9-[(3’,5’-di-O-acetyl-2’-deoxy)-β-D-ribofuranosyl]purine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
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In methanol at 0 - 20℃; for 6h; Inert atmosphere; | 69% |
(2R,3S,5R)-5-(2-Amino-6-methoxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 0.166667h; | 54% |
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(imidazol-1-yl)purine
methanol
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
With Dowex 1 x 2 (OH-) resin at 20℃; | 52% |
trimethylsulphonium hydroxide
2'-Deoxyguanosine
A
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
B
N1-methyl-2'-deoxyguanosine
C
2'-deoxy-7-methylguanosine
D
9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-methyl-2-methylamino-1,9-dihydro-purin-6-one
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Further byproducts given; | A 6 mg B 23% C n/a D 7 mg |
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Further byproducts given; | A 6 mg B 19 mg C n/a D 7 mg |
sodium methylate
2'-Deoxyguanosine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
Conditions | Yield |
---|---|
With pyridine; trifluoroacetic anhydride 1. ice bath, 10 min, 2. methanol, 24 h; Yield given. Multistep reaction; |
1-methyl-1-nitrosourea
2'-Deoxyguanosine
A
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
B
N1-methyl-2'-deoxyguanosine
C
methylphosphate
D
dimethylphosphoric acid
E
7-methylguanine
F
N7-Me-dGuo
Conditions | Yield |
---|---|
With sodium hydroxide; phosphate buffer In methanol; water at 37℃; Product distribution; various pH values; |
N2-phenylacetyl-O6-methoxycarbonylmethyl-2'-deoxyguanosine
A
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine
B
[2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yloxy]-acetic acid methyl ester
Conditions | Yield |
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With potassium carbonate In methanol at 20℃; Product distribution; Further Variations:; Reagents; Hydrolysis; |