Reference

Optically active 2-(4-hydroxyphenoxy)propionic acid

Optically active 2-(4-hydroxyphenoxy)propionic acid. Fujinawa, Shoji; Hashiba, Isao; Suzuki, Kenji; Tsuchiya, Shuji; Takakuwa, Yasuo (Nissan Chemical Industries, Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 61158947 A2 18 Jul 1986 Showa, 5 pp. (Japan) CODEN: JKXXAF.There are some reagents with their cas registry numbers 96562-58-2 and 94050-90-5 are used in this study. CLASS: ICM: C07C059-125. ICS: C07C051-367. ICA: B01J031-02; C07B053-00. APPLICATION: JP 84-279711 28 Dec 1984. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 5 The title acid (I), useful as an intermediate for herbicides (no data), is prepd. by reaction of XCHMeCO2M (II; X = Cl, Br; M = H, alkali metal) with hydroquinone (III) or its alkali salts in the presence of alkali hydroxides and H2O. Thus, sapon. of 98 g l-ClCHMeCO2Me with aq. NaOH at 20-40° gave l-II (X = Cl, M = Na), which was treated with 110 g II in H2O at 40° under N to give d-I, which was esterified with EtOH in the presence of H2SO4 to give 147 g d-I Et ester with 93% enantiomer excess. .