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Detail of "980-71-2"

  • CAS Number:
  • 980-71-2
  • Name:

  • Brompheniramine hydrogen maleate

  • Molecular Structure:
  • Formula:
  • C16H19BrN2·C4H4O4
  • Molecular Weight:
  • 435.31
  • Deleted CAS:
  • 32865-01-3 |8055-73-0
  • Synonyms:
  • Brompheniramine maleate;Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1);gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine;Dimetane Extentabs;Parabromdylamine maleate;2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate;Dimetapp Elixir;Veltane;Ebalin;Spentane;Lodrane Liquid;Dristan Allergy;2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1);Drixoral Syrup;Dimetane;Brompheniramine maleate (USP);Gammistin;Dimotane;2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);Brompheniraminum [INN-Latin];Dimetapp allergy;Rolabromophen;Prestwick_913;Dimetapp DM;2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (+-)-, (Z)-2-butenedioate (1:1);Drauxin;Allent;Dimetapp Childrens Chewable;Bromopheniramine maleate;Dimetapp Tablets;Dimetapp allergy (TN);2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-, (Z)-butenedioate (1:1);2-Pyridinepropanamine,?-(4-bromophenyl)-N,- N-dimethyl-,(2Z)-2-butenedioate (1:1);
  • EINECS:
  • 213-562-9
  • Melting Point:
  • 134-135 °C
  • Boiling Point:
  • 403 °C at 760 mmHg
  • Flash Point:
  • 197.5 °C
  • Solubility:
  • soluble in water, less soluble in alcohol
  • Appearance:
  • white solid
  • Hazard Symbols:
  • HarmfulXn,IrritantXi
  • Risk Codes:
  • 22
  • Safety:
  • 36 Details
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Reference

Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography
Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography. Ghanekar, A. G.; Das Gupta, V. (Coll. Pharm., Univ. Houston, Houston, Tex., USA). Am. J. Hosp. Pharm., 34(6), 651-3 (English) 1977. CODEN: AJHPA9. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Brompheniramine maleate [980-71-2], chlorpheniramine maleate [113-92-8], pheniramine maleate [132-20-7], and pyrilamine maleate [59-33-6] were sepd. and assayed accurately by high-pressure liq. chromatog. on a column contg. cyanopropylsilane permanently bonded to Si-C bond using 0.05 M KH2PO4 in water contg. 10% by vol. MeOH and 0.16% by vol. HOAc as the solvent. The std. deviations in the detn. of the above compds. were 1.90, 1.99, 1.31, and 2.14%, resp. Interferences and potential interferences by other common ingredients were described.
The effect of environmental conditions on the release of brompheniramine from protein/wax matrix tablets
The effect of environmental conditions on the release of brompheniramine from protein/wax matrix tablets. Groves, M. J.; Galindez, F. E. (Chelsea Coll., Univ. London, London, Engl.). Acta Pharm. Suec., 13(4), 373-84 (English) 1976. CODEN: APSXAS. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Brompheniramine maleate (I maleate) [980-71-2] in vitro release from tablets contg. Carnauba wax, cetostearyl alc. [8005-44-5], glyceryl monostearate [31566-31-1], but no casein in 0.1N HCl and pH 3 buffer or acid and pH buffer was calcd. by the Higuchi (1963) method to be 1.21 and 1.44 and was found to be 1.22 and 1.45. When casein was added to the tablet, I release in 0.1N HCl remained about const., but at pH 8 increasing casein concns. increased I release rate. Pepsin [9001-75-6] and trypsin [9002-07-7] did not affect the soln. rate of tablets lacking casein, but did affect soln. rate when the tablets contained casein.
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