Reference

Effect of No-Spa on liver glucocorticoid receptors and biochemistry of homeostasis in adrenalectomized rats

Effect of No-Spa on liver glucocorticoid receptors and biochemistry of homeostasis in adrenalectomized rats. Golikov, P. P.; Nikolaeva, N. Yu.; Kirillova, E. G.; Matveev, S. B. (Nauchno-Issled. Inst. Skoroi Pomoshchi, Moscow, USSR). Farmakol. Toksikol. (Moscow), 47(3), 59-62 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 In adrenalectomized male rats, No-Spa (I) [985-12-6] (0.2 mL of 2% soln./100 g, 3 times) increased significantly the level of type-II and -III glucocorticoid receptors in liver cytosol, and the content of glucose and protein in the blood and liver. Animals receiving No-Spa demonstrated a substantial increase in O partial tension and O-satn. of venous Hb.

Use of hypothermia for investigating the main methods of pharmacological protection of the myocardium from damage in the early period of acute ischemia

Use of hypothermia for investigating the main methods of pharmacological protection of the myocardium from damage in the early period of acute ischemia. Urakov, A. L. (USSR). Deposited Doc., VINITI 6954-83, 13 pp. Avail. VINITI (Russian) 1983. DOCUMENT TYPE: Report CA Section: 1 (Pharmacology) Studies of blood coagulation and myocardial respiration in dogs and rats in the early period after acute ischemia showed that hypothermia and certain malonate-like cardioprotectants (papaverine [58-74-2], No-Spa [985-12-6], nonachlazine [49780-10-1], pipolphen [58-33-3], and ethmozine [29560-58-5]) are of therapeutic value, and that hypothermia may be a useful std. with which to evaluate the protective efficacy of pharmaceutical prepns.