1006-08-2 Usage
Description
6-Hydroxy-7-methylpurine, a pyrrolopyrimidine derivative, is an organic compound with a purine base featuring a pyrrolo[2,3-d]pyrimidine moiety. It exhibits a slightly polar nature due to the presence of hydroxy and methyl functional groups. 6-HYDROXY-7-METHYLPURINE plays a significant role as an intermediate in various biochemical processes, particularly in DNA repair mechanisms. However, its excessive accumulation can be detrimental to living organisms, highlighting the importance of well-regulated metabolic pathways. The structure, properties, and biological roles of 6-Hydroxy-7-methylpurine are currently under investigation in biochemical and pharmacological research.
Uses
Used in Biochemical Research:
6-Hydroxy-7-methylpurine is used as a research compound for studying its structure, properties, and biological roles in biochemical and pharmacological contexts. Its involvement in DNA repair mechanisms and potential harmful effects when accumulated excessively make it an important subject for understanding metabolic pathways and developing therapeutic strategies.
Used in Drug Development:
6-Hydroxy-7-methylpurine can be utilized as a starting material or intermediate in the synthesis of pharmaceutical compounds targeting DNA repair mechanisms or other related biological processes. Its unique structure and properties may offer novel therapeutic opportunities in the treatment of diseases associated with DNA damage or repair deficiencies.
Used in Diagnostic Applications:
Due to its role in DNA repair mechanisms, 6-Hydroxy-7-methylpurine may be employed as a biomarker or diagnostic tool for assessing the status of DNA repair pathways in various diseases or conditions. Monitoring its levels or activity could provide valuable insights into the health of an individual's DNA repair mechanisms and potential risks for certain diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1006-08-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1006-08:
(6*1)+(5*0)+(4*0)+(3*6)+(2*0)+(1*8)=32
32 % 10 = 2
So 1006-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N4O/c1-10-3-9-5-4(10)6(11)8-2-7-5/h2-3H,1H3,(H,7,8,11)
1006-08-2Relevant articles and documents
Purines. LIX. An alternative synthesis of 7-alkyl-1-methyladenines by regioselective alkylation, fission, and reclosure of the adenine ring
Fujii,Saito,Suzuki,Kunugi
, p. 151 - 153 (1994)
7-Alkyl-1-methyladenines (12a,b) have been synthesized from 1-alkyl-4- aminoimidazole-5-carboxamides (5a,b) in two steps [hence from adenine (1) in six steps]. The synthesis started with dehydration (using POCl3-HCONMe2) of 5a,b, rea
OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS
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, (2019/09/30)
The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
NEW TRPA1 ANTAGONISTS
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Page/Page column 35; 39, (2017/05/02)
The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.
Purines. LXXV. Dimroth rearrangement, hydrolytic deamination, and pyrimidine-ring breakdown of 7-alkylated 1-alkoxyadenines: N(1)-C(2) versus N(1)-C(6) bond fission
Itaya, Taisuke,Ito, Nobuaki,Kanai, Tae,Fujii, Tozo
, p. 832 - 841 (2007/10/03)
On treatment with boiling H2O for 5-6h, 1-alkoxy-7-alkyladenines (13) underwent hydrolytic cleavage of the N(1)-C(2) and the N(1)-C(6) bonds to produce the imidazole-5-carboxamidines (14) in 53-60% yields and the imidazole-5-carboxamides (18) i
