1007-11-0Relevant articles and documents
Barriers to Rotation of the Dimethylamino Group in Some 2-Amino-4-(N,N-dimethylamino)pyrimidines
Wells, C. H. J.
, p. 274 - 275 (1982)
The free energy of activation for rotation about the exocyclic C-N bond of the dimethylamino group of some 6-substituted 2-amino-4-(N,N-dimethylamino)pyrimidines has been determined using 1H NMR line shape analysis.The results are discussed in terms of the relative electron-withdrawing and electron-releasing effects of the substituents.
CHEMICAL COMPOUNDS
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Page/Page column 121, (2010/07/10)
The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.