107843-77-6Relevant articles and documents
Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans
?una, Kristina,Brkanac, Sandra Radi?,Cardullo, Nunzio,Crnolatac, Ivo,Durgo, Ksenija,Glava?-Obrovac, Ljubica,Hu?ek, Ana,Juki?, Marijana,Muccilli, Vera,Pulvirenti, Luana,Stojkovi?, Marijana Radi?,Tringali, Corrado,Tumir, Lidija-Marija,Zonji?, Iva
, (2020)
Interactions of two newly synthesized and six previously reported benzoxanthene lignans (BXLs), analogues of rare natural products, with DNA/RNA, G-quadruplex and HSA were evaluated by a set of spectrophotometric methods. Presence/absence of methoxy and hydroxy groups on the benzoxanthene core and minor modifications at C-1/C-2 side pendants – presence/absence of phenyl ring and presence/absence of methoxy and hydroxy groups on phenyl ring – influenced the fluorescence changes and the binding strength to double-stranded (ds-) and G-quadruplex structures. In general, compounds without phenyl ring showed stronger fluorescence changes upon binding than phenyl-substituted BXLs. On the other hand, BXLs with an unsubstituted phenyl ring showed the best stabilization effects of G-quadruplex. Circular dichroism spectroscopy results suggest mixed binding mode, groove binding and partial intercalation, to ds-DNA/RNA and end-stacking to top or bottom G-tetrads as the main binding modes of BXLs to those targets. All compounds exhibited micromolar binding affinities toward HSA and an increased protein thermal stability. Moderate to strong antiradical scavenging activity was observed for all BXLs with hydroxy groups at C-6, C-9 and C-10 positions of the benzoxanthene core, except for derivative bearing methoxy groups at these positions. BXLs with unsubstituted or low-substituted phenyl ring and one derivative without phenyl ring showed strong growth inhibition of Gram-positive Staphylococcus aureus. All compounds showed moderate to strong tumor cell growth-inhibitory activity and cytotoxicity.
A method for preparing coffee acid benzyl ester
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Page/Page column 5-7, (2019/03/28)
The invention discloses a coffee acid benzyl ester of preparation method, the overall steps are: a, the caffeic acid dissolved in organic solvent, the reaction is carried out by adding thionyl chloride, make intermediate A; b, alkali and the presence of o
Protective effect of caffeic acid derivatives on tert-butyl hydroperoxide-induced oxidative hepato-toxicity and mitochondrial dysfunction in HepG2 cells
Tsai, Tzung-Hsun,Yu, Chun-Hsien,Chang, Yu-Ping,Lin, Yu-Ting,Huang, Ching-Jang,Kuo, Yueh-Hsiung,Tsai, Po-Jung
, (2017/06/08)
Oxidative stress results in structural and functional abnormalities in the liver and is thought to be a crucial factor in liver diseases. The aim of this study was to investigate the cytoprotective and antioxidant effects of caffeic acid (CA) derivatives
