112984-60-8Relevant articles and documents
Ulifloxacin hydrochloride crystal and its preparation method and use
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Paragraph 0063; 0064, (2018/03/01)
The invention provides an ulifloxacin hydrochloride crystal. The X-ray powder diffraction pattern of the ulifloxacin hydrochloride crystal under Cu-K alpha radiation has peaks at 2 theta angles of 8.362+/-0.2 degrees, 9.513+/-0.2 degrees, 12.663+/-0.2 degrees, 21.253+/-0.2 degrees and 24.129+/-0.2 degrees. The invention provides a preparation method of the crystal, a pharmaceutical composition comprising the crystal and a pharmaceutical use of the crystal and the pharmaceutical composition. The ulifloxacin hydrochloride crystal has good reproducibility. The preparation method is simple and reduces the dosage of the organic solvent. Experiments prove that the novel crystal and the mother crystal of ulifloxacin hydrochloride have significant effects in the aspects of solubility, stability, hygroscopicity and in-vivo therapeutic effects. The novel crystal can be processed into a variety of dosage forms and has good clinical application potential.
A method for preparing of plurichari (by machine translation)
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Paragraph 0024; 0037; 0038; 0039, (2016/10/07)
The invention relates to a prepration method of a compound prulifloxacin as shown in the formula (I), wherein the chemical name of prulifloxacin is 6-floro-1-methyl-7-[4-(5-methyl-2-oxo1,3-dioxo hetercyclopentene-4-yl)methyl-1-piperazinyl-4-oxo-4H-[1,3] thiaazacyclobutane[3,2-a] quinoline-3-carboxylic acid. The preparation method provided by the invention is a preparation method of prulifloxacin suitable for industrialized production, simple in process, high in purity and high in yield.
PROCESS FOR THE PREPARATION OF HIGHLY PURE PRULIFLOXACIN
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Page/Page column 15, (2009/09/05)
The present invention provides an industrially advantageous process for the preparation of highly pure prulifloxacin of formula I and its pharmaceutically acceptable salts. The present i innvention a also provides a novel process for the purification of prulifloxacin acid addition salt.