113-52-0Relevant articles and documents
POLYMORPHS OF IMIPRAMINE HYDROCHLORIDE AND PAMOATE SALT
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Page/Page column 5, (2009/05/28)
The present invention relates to novel polymorphs of imipramine salts and the processes for their preparation.
TCI America
(I0971) Imipramine Hydrochloride >98.0%(HPLC)
113-52-0
1g
390.00CNY
TCI America
(I0971) Imipramine Hydrochloride >98.0%(HPLC)
113-52-0
5g
790.00CNY
TCI America
(I0971) Imipramine Hydrochloride >98.0%(HPLC)
113-52-0
25g
2,790.00CNY
Cerilliant
(I-902) Imipramine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
113-52-0
I-902-1ML
263.25CNY
Version: 1.0
Creation Date: Aug 10, 2017
Revision Date: Aug 10, 2017
Product name | imipramine hydrochloride |
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Product number | - |
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Other names | 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride |
Identified uses | For industry use only. |
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Uses advised against | no data available |
Emergency phone number | - |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
More Details:113-52-0 SDS
Reaxys ID: 19040915
Imipramine hydrochloride
Conditions | Yield |
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Stage #1: In acetone for 0.5h; Heating / reflux; Stage #2: In di-isopropyl ether at 0 - 5℃; |
Conditions | Yield |
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In water E-2 M solns. were mixed; ppt. was filtered, thoroughly washed with distd. water, dried at room temp., elem. anal.; | 99.5% |
Conditions | Yield |
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In water E-2 M solns. were mixed; ppt. was filtered, thoroughly washed with distd. water, dried at room temp., elem. anal.; | 99.5% |
Conditions | Yield |
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In water at 20 - 62℃; for 19.95h; | 95.1% |
In water at 20 - 62℃; for 19.95h; | 95.1% |
Imipramine hydrochloride
N,N-dimethyl-formamide
2-Formylimipramine
Conditions | Yield |
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With trichlorophosphate at 100℃; for 4h; Formylation; Vilsmeier Reaction; | 59% |
Imipramine hydrochloride
orthoformic acid triethyl ester
[3-(2-{Bis-[5-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl]-methyl}-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-amine
Conditions | Yield |
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With tetrafluoroboric acid diethyl ether In diethyl ether; dichloromethane for 6h; Ambient temperature; | 8% |
Imipramine hydrochloride
A
desipramine
B
9,10-dihydrodibenzazepine
C
10-Hydroxyimipramine
Conditions | Yield |
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In water Ambient temperature; M. griseo-cyanus (ATCC 1207a); further microbial agents; | A 10 mg B n/a C n/a |
Imipramine hydrochloride
A
desipramine
B
9,10-dihydrodibenzazepine
C
10-Hydroxyimipramine
D
2-hydroxyimipramine
Conditions | Yield |
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In water for 480h; Ambient temperature; C. blakesleeana (ATCC 8688a); further microbial agents; Further byproducts given; | A n/a B n/a C 30 mg D 88 mg |
Imipramine hydrochloride
A
9,10-dihydrodibenzazepine
B
10-Hydroxyimipramine
C
2-hydroxyimipramine
D
imipramine N-oxide
Conditions | Yield |
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In water; N,N-dimethyl-formamide for 480h; Ambient temperature; C. blakesleeana (ATCC 8688a); further microbial agents; Further byproducts given; | A n/a B 30 mg C 88 mg D n/a |
Imipramine hydrochloride
A
9,10-dihydrodibenzazepine
B
imipramine N-oxide
Conditions | Yield |
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In water; N,N-dimethyl-formamide for 360h; Ambient temperature; F. oxysporum f. sp. cepae (ATCC 11711); further microbial agents; | A 7 mg B n/a |
In water for 312h; Ambient temperature; A. flavipes (ATCC 16795); further microbial agents; | A n/a B 112 mg |
Imipramine hydrochloride
C19H20(2)H4N2*ClH
Conditions | Yield |
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With deuteroacetic acid; sulfuric acid-d2 at 100℃; for 1.5h; in sealed tube; Yield given; |
Imipramine hydrochloride
Conditions | Yield |
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With sulfuric acid |
Imipramine hydrochloride
Conditions | Yield |
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With iron(III) chloride; acetic acid at 75℃; for 0.0833333h; |
Conditions | Yield |
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at 280 - 326℃; Kinetics; |
Conditions | Yield |
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With NADP; cDNA-expressed human recombinant CYP1A2 In phosphate buffer at 37℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; concentration; |
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 59 percent / POCl3 / 4 h / 100 °C 2: m-CPBA; TFA / CH2Cl2 / 2 h / 5 - 20 °C 3: conc. HCl / methanol / 2 h View Scheme |
Imipramine hydrochloride
formic acid 5-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl ester
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 59 percent / POCl3 / 4 h / 100 °C 2: m-CPBA; TFA / CH2Cl2 / 2 h / 5 - 20 °C View Scheme |
Imipramine hydrochloride
3-Hydroxy-2-naphthoic acid
imipramine xinafoate
Conditions | Yield |
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In water at 25 - 50℃; for 20h; |
Conditions | Yield |
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Stage #1: disodium pamoate; Imipramine hydrochloride In water; acetone at 20 - 55℃; Stage #2: In water at 40 - 70℃; | |
In water at 5℃; |
impramine
Imipramine hydrochloride
embonic acid disodium salt
imipramine pamoate
Conditions | Yield |
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With sodium hydroxide In water |
Conditions | Yield |
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With peroxidase from horseradish type VI; dihydrogen peroxide at 37℃; for 1h; pH=7; aq. phosphate buffer; Enzymatic reaction; |
Imipramine hydrochloride
Conditions | Yield |
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With zinc(II) chloride at 60 - 100℃; for 24h; Inert atmosphere; Sealed tube; |
Conditions | Yield |
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With NADP+; D-glucose-6- In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 1h; pH=7.4; Enzymatic reaction; |
Imipramine hydrochloride
2-hydroxynaphthalene-3-carboxylic acid sodium salt
Conditions | Yield |
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In water at 50℃; for 20h; | 12.7 g |
Conditions | Yield |
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With sodium hydroxide In water |
Imipramine hydrochloride
Conditions | Yield |
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In aq. phosphate buffer pH=7.4; UV-irradiation; |
The aggregation behavior and interaction of an amphiphilic antidepressant drug imipramine (IMP) hydrochloride with the cationic surfactant cetyltrimethylammonium bromide (CTAB) have been studied using light scattering (both static and dynamic) techniques. Due to rigid tricyclic hydrophobic moiet...detailed
Benzidine and o-tolidine, the hazardous carcinogens are still in use for the detection of blood in urine. Development of safer substitutes are of paramount importance. Unfortunately, the alternate available reagents lack specificity, sensitivity and reproducibility. Imipramine hydrochloride (IPH...detailed
The effect of various additives used in pharmaceutical formulations (inorganic salts, QABs, amino acids, sugars, alcohols, ureas) has been seen by studying the clouding phenomenon of imipramine hydrochloride (IMP) drug in solution. At fixed pH values, increasing inorganic salt concentrations cau...detailed
Herein, we have checked the interaction between the imipramine hydrochloride (IMH, an antidepressant drug) and anionic surfactant dioctyl sulfosuccinate sodium salt (AOT) mixed system through a conductometric method in aqueous medium along with electrolyte solutions at different temperatures (28...detailed
Imipramine hydrochloride (IMP) is a drug which is amphiphilic. Its interaction with gemini surfactants 14-s-14 (s = 4, 5, 6) has been investigated at different temperatures employing conductimetric measurements. The experimentally determined critical micelle concentration (cmc) values come out t...detailed
The micellization phenomena in the mixed system of the amphiphilic antidepressant drug imipramine hydrochloride (IPH) and cationic hydrotropes - aniline hydrochloride (AnH), ortho-toluidine hydrochloride (o-ToH), as well as para-toluidine hydrochloride (p-ToH)- in a water solution at a range of ...detailed
The present invention relates to novel polymorphs of imipramine salts and the processes for their preparation.