114522-12-2 Usage
Description
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]is a modified form of the nucleoside uridine, featuring a complex structure with multiple phenyl and nitro groups attached to the uridine molecule. This chemical modification can potentially alter the biological and pharmacological properties of uridine, affecting its interactions with enzymes, receptors, and transporters in the body. Ongoing research is exploring the specific effects and potential applications of this modified uridine compound.
Uses
Used in Pharmaceutical Industry:
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-O-[2-(4-nitrophenyl)ethyl]is used as a research compound for investigating its potential biological and pharmacological properties. The chemical modification may provide insights into the interactions of uridine with various enzymes, receptors, and transporters, leading to the development of new therapeutic agents.
Used in Biochemical Research:
This modified uridine compound is used as a tool in biochemical research to study the effects of structural modifications on the properties and functions of nucleosides. Understanding these effects can contribute to the advancement of nucleoside-based drug discovery and the development of novel therapeutic strategies.
Note: The specific applications and industries for this compound may not be fully known or established at this time, as research is ongoing. The uses listed above are based on the potential implications of the chemical modification and its impact on the biological and pharmacological properties of uridine.
Check Digit Verification of cas no
The CAS Registry Mumber 114522-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,5,2 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114522-12:
(8*1)+(7*1)+(6*4)+(5*5)+(4*2)+(3*2)+(2*1)+(1*2)=82
82 % 10 = 2
So 114522-12-2 is a valid CAS Registry Number.
114522-12-2Relevant articles and documents
Nucleosides. Part LIX. The 2-(4-nitrophenyl)ethylsulfonyl (Npes) group: A new type of protection in nucleoside chemistry
Pfister,Schirmeister,Mohr,Farkas,Stengele,Reiner,Dunkel,Gokhale,Charubala,Pfleiderer
, p. 1705 - 1737 (2007/10/02)
The 2-(4-nitrophenyl)ethylsulfonyl (npes) group is developed as a new sugar OH-blocking group in the ribonucleoside series. Its cleavage can be performed in a β-eliminating process under aprotic conditions using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as the most effective base. Since sulfonates do not show acyl migration, partial protection of 1,2-cis-diol moieties is possible leading to new types of oligonucleotide building blocks. A series of Markiewicz-protected ribonucleosides 1-10 is converted into their 2'-O-[2-(4-nitrophenyl)ethylsulfonyl] derivatives 29-38 in which the 5'-O-Si bond can be cleaved by acid hydrolysis forming 39-45. Subsequent monomethoxytritylation leads to 46-50, and desilylation affords the 5'-O-(monomethoxytrityl)-2'-O-[2-(4-nitrophenyl)ethylsulfonyl]ribonucl eosides 51-55. Acid treatment to remove trityl groups do also not harm the npes group(→ 56-58). Unambiguous syntheses of fully blocked 2'-O-[2-(4-nitrophenyl)ethylsulfonyl]ribonucleosides 96-102 are achieved from the corresponding 3'-O-(tert-butyl)dimethylsilyl derivatives. Furthermore, various base-protected 5'-O-(monomethoxytrityl)- and 5'-O-(dimethoxytrityl)ribonucleosides, i.e. 59-77, are treated directly with 2-(4-nitrophenyl)ethylsulfonyl chloride forming in all cases a mixture of the 2',3'-di-O- and the two possible 2'- and 3'-O-monosulfonates 107-148 which can be separated into the pure components by chromatographic methods. The npes group is more labile towards DBU cleavage than the corresponding base-protecting 2-(4-nitrophenyl)ethyl (npe) and 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) groups allowing selective deblocking which is of great synthetic potential.
