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124728-93-4

124728-93-4

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124728-93-4 Usage

General Description

2,3-Difluoro-1-propoxybenzene is a chemical compound with the molecular formula C9H9F2O. It is a colorless liquid with a strong, sweet odor, and it is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound is known to be flammable and may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. It is important to handle 2,3-difluoro-1-propoxybenzene with care and follow proper safety protocols when working with it in a laboratory or industrial setting.

Check Digit Verification of cas no

The CAS Registry Mumber 124728-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,7,2 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 124728-93:
(8*1)+(7*2)+(6*4)+(5*7)+(4*2)+(3*8)+(2*9)+(1*3)=134
134 % 10 = 4
So 124728-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H10F2O/c1-2-6-12-8-5-3-4-7(10)9(8)11/h3-5H,2,6H2,1H3

124728-93-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-difluoro-3-propoxybenzene

1.2 Other means of identification

Product number -
Other names 1,2-difluoro-3-n-propyloxybenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124728-93-4 SDS

124728-93-4Synthetic route

2,3-difluorophenol
6418-38-8

2,3-difluorophenol

1-iodo-propane
107-08-4

1-iodo-propane

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions
ConditionsYield
With sodium carbonate In ethanol; water92%
1-Chloropropane
540-54-5

1-Chloropropane

2,3-difluorophenol
6418-38-8

2,3-difluorophenol

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium hydroxide In water; N,N-dimethyl-formamide; toluene at 30℃; Reflux; Industrial scale;90.6%
1,2-difluoro-3-(prop-2-yn-1-yloxy)benzene
890840-88-7

1,2-difluoro-3-(prop-2-yn-1-yloxy)benzene

7,8-difluoro-2H-chromene
1029476-86-5

7,8-difluoro-2H-chromene

A

7,8-difluoro-3,4-dihydro-1-benzopyran
1029476-87-6

7,8-difluoro-3,4-dihydro-1-benzopyran

B

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran at 20℃; for 1h;
propan-1-ol
71-23-8

propan-1-ol

1,2,3-trifluorobenzene
1489-53-8

1,2,3-trifluorobenzene

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions
ConditionsYield
With calcium hydroxide at 100℃; for 20h;
Trimethyl borate
121-43-7

Trimethyl borate

sec.-butyllithium
598-30-1

sec.-butyllithium

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2,3-difluoro-4-propyloxyphenyl boric acid

2,3-difluoro-4-propyloxyphenyl boric acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; hexane62%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

4-Propoxy-2,3-difluorobenzaldehyde

4-Propoxy-2,3-difluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃;
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-propyl-phenyl)-[1,3]dioxane

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-propyl-phenyl)-[1,3]dioxane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
1.2: hexane; tetrahydrofuran / -78 - 20 °C
2.1: p-toluenesulfonic acid / toluene / Heating
View Scheme
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

5-(4-butyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

5-(4-butyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
1.2: hexane; tetrahydrofuran / -78 - 20 °C
2.1: p-toluenesulfonic acid / toluene / Heating
View Scheme
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-pentyl-phenyl)-[1,3]dioxane

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-pentyl-phenyl)-[1,3]dioxane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
1.2: hexane; tetrahydrofuran / -78 - 20 °C
2.1: p-toluenesulfonic acid / toluene / Heating
View Scheme
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(2-fluoro-4-pentyl-phenyl)-[1,3]dioxane

2-(2,3-difluoro-4-propoxy-phenyl)-5-(2-fluoro-4-pentyl-phenyl)-[1,3]dioxane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
1.2: hexane; tetrahydrofuran / -78 - 20 °C
2.1: p-toluenesulfonic acid / toluene / Heating
View Scheme
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

5-(2,3-difluoro-4-pentyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

5-(2,3-difluoro-4-pentyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
1.2: hexane; tetrahydrofuran / -78 - 20 °C
2.1: p-toluenesulfonic acid / toluene / Heating
View Scheme
4-(trans-4-n-propylcyclohexyl)cyclohexanone
82832-73-3

4-(trans-4-n-propylcyclohexyl)cyclohexanone

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

C24H36F2O2

C24H36F2O2

Conditions
ConditionsYield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75 - -70℃; for 2h; Inert atmosphere; Large scale;
Stage #2: 4-(trans-4-n-propylcyclohexyl)cyclohexanone In tetrahydrofuran; hexane at -75 - -30℃; for 2.5h; Inert atmosphere; Large scale;
4-(trans-4-n-propylcyclohexyl)cyclohexanone
82832-73-3

4-(trans-4-n-propylcyclohexyl)cyclohexanone

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

C24H34F2O

C24H34F2O

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 - -70 °C / Inert atmosphere; Large scale
1.2: 2.5 h / -75 - -30 °C / Inert atmosphere; Large scale
2.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Large scale
View Scheme
4-(trans-4-n-pentylcyclohexyl)cyclohexanone
84868-02-0

4-(trans-4-n-pentylcyclohexyl)cyclohexanone

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

C26H40F2O2

C26H40F2O2

Conditions
ConditionsYield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75 - -70℃; for 2h; Inert atmosphere; Large scale;
Stage #2: 4-(trans-4-n-pentylcyclohexyl)cyclohexanone In tetrahydrofuran; hexane at -75 - -30℃; for 2.5h; Inert atmosphere; Large scale;
4-(trans-4-n-pentylcyclohexyl)cyclohexanone
84868-02-0

4-(trans-4-n-pentylcyclohexyl)cyclohexanone

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

C26H38F2O

C26H38F2O

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 - -70 °C / Inert atmosphere; Large scale
1.2: 2.5 h / -75 - -30 °C / Inert atmosphere; Large scale
2.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Large scale
View Scheme
Trimethyl borate
121-43-7

Trimethyl borate

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; potassium tert-butylate In tetrahydrofuran; hexane at -78 - -70℃; for 0.5h; Inert atmosphere;
Stage #2: Trimethyl borate In tetrahydrofuran; hexane for 0.5h;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 1h;		8.2 g
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxyphenyl)-4,5-bis(trifluoromethyl)-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene

2-(2,3-difluoro-4-propoxyphenyl)-4,5-bis(trifluoromethyl)-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 0.5 h / -78 - -70 °C / Inert atmosphere
1.2: 0.5 h
1.3: 1 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / Reflux; Inert atmosphere
View Scheme
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

2,3-difluorophenol
6418-38-8

2,3-difluorophenol

Conditions
ConditionsYield
With iron(III) chloride In ethanol at 30℃; for 3h;10.6 g
1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

6-butoxy-2-(4-propyloxy-2,3-difluorophenyl)-3,4,5-trifluoronaphthalene

6-butoxy-2-(4-propyloxy-2,3-difluorophenyl)-3,4,5-trifluoronaphthalene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 - -3 °C
2: triphenylphosphine; potassium carbonate; palladium diacetate / tetrahydrofuran; water / 5 h / Reflux
View Scheme
Triisopropyl borate
5419-55-6

Triisopropyl borate

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -10 - -3℃; for 1h;48 g
boric acid tributyl ester
688-74-4

boric acid tributyl ester

1,2-difluoro-3-n-propoxybenzene
124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium In 2-methyltetrahydrofuran; cyclohexane at -70 - -60℃; for 2h; Inert atmosphere;
Stage #2: boric acid tributyl ester In 2-methyltetrahydrofuran; cyclohexane at -70 - -60℃; for 2h;

124728-93-4Downstream Products

124728-93-4Relevant articles and documents

Synthesis technology of 2,3-difluorophenol

-

Paragraph 0015; 0041-0042, (2018/10/11)

The invention relates to a synthesis technology of 2,3-difluorophenol. 1,2,3-trifluoro-benzene is used as a raw material, and 2,3-difluorophenol is prepared through oxyalkylation and dealkylation reactions. The synthesis route is short, the technology operation is simple, special equipment is not needed, the yield reaches 82% or above, and the synthesis technology has good industrial prospects.

FUROCHROMAN DERIVATIVES

-

Page/Page column 43, (2008/12/07)

Disclosed are furochroman compounds of formula I liquid-crystal media which contains the compounds of formula I, and the use of the media in electro-optical displays, in particular in VAN LCDs.

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