127257-87-8 Usage
Classification
Pyrrole derivative
It is an organic compound containing a five-membered ring with one nitrogen atom.
Structural features
Presence of a bromine atom attached to the phenyl group.
Two methyl groups attached to the pyrrole ring.
Organic synthesis
The compound can be used as a building block in the synthesis of other compounds.
Pharmaceutical research
It may be used as a starting material for the development of new drugs.
Materials science
The compound may have properties that make it useful in this field.
Other industrial applications
Its unique structural properties may lead to further uses in various industries.
Chemical reactivity
The presence of the bromine atom and the nitrogen atom in the pyrrole ring may contribute to the compound's reactivity, allowing it to participate in various chemical reactions.
Stability
The compound's stability may be influenced by the presence of the bromine atom and the methyl groups, which can affect its reactivity and susceptibility to degradation.
Solubility
The compound's solubility in different solvents may be influenced by its molecular structure, particularly the presence of the bromine atom and the methyl groups.
Melting and boiling points
The compound's melting and boiling points may be affected by the strength of the intermolecular forces between its molecules, which can be influenced by the bromine atom and the methyl groups.
Density
The compound's density may be influenced by its molecular weight and the arrangement of its atoms in space.
Check Digit Verification of cas no
The CAS Registry Mumber 127257-87-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,2,5 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127257-87:
(8*1)+(7*2)+(6*7)+(5*2)+(4*5)+(3*7)+(2*8)+(1*7)=138
138 % 10 = 8
So 127257-87-8 is a valid CAS Registry Number.
127257-87-8Relevant articles and documents
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: Effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype
Artico, Marco,Carletti, Raffaella,Fioravanti, Rossella,Mai, Antonello,Morrone, Stefania,Nebbioso, Marcella,Nicolai, Alice,Ragno, Rino,Romanelli, Annalisa,Sabatino, Manuela,Scarpa, Susanna,Stazi, Giulia,Taglieri, Ludovica,Taurone, Samanta,Valente, Sergio
, (2019)
Background: Glioblastoma (GBM) is the most lethal and aggressive malignant primary brain tumor in adults. After surgical resection of the tumor, the patient typically should be subjected to chemotherapy (temozolomide, TMZ) and concomitant radiotherapy. Si
Efficient synthesis of substituted pyrroles through Pd(OCOCF3)2-catalyzed reaction of 5-hexen-2-one with primary amines
Chen, Xi,Yang, Meng,Zhou, Min
supporting information, p. 5215 - 5218 (2016/11/11)
An efficient and facile Pd(OCOCF3)2-catalyzed one-pot cascade protocol has been developed for the synthesis of multiple substituted pyrroles in good to excellent yields. Unlike the reported method starting from the 2-alkenal-1,3-carbonyl compounds, the process utilizes the less reactive 5-hexen-2-one and the method has great potential as a complement to the current developed methods.
Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
-
Page/Page column 139, (2008/06/13)
The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
