13788-84-6 Usage
Description
3-METHYL-4-PHENYLPYRAZOLE, also known as 3-Methyl-4-phenyl-1H-pyrazole, is an organic compound with the chemical formula C10H10N2. It is a pale yellow solid and is primarily used in organic synthesis due to its unique chemical properties and structure.
Uses
Used in Organic Synthesis:
3-METHYL-4-PHENYLPYRAZOLE is used as a synthetic building block for the development of various chemical compounds. Its application in organic synthesis is due to its ability to undergo a range of chemical reactions, such as substitution, addition, and condensation, which allows for the creation of diverse molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-METHYL-4-PHENYLPYRAZOLE is used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique chemical structure makes it a valuable component in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
3-METHYL-4-PHENYLPYRAZOLE is also utilized in chemical research as a model compound to study various reaction mechanisms and to understand the properties of similar organic compounds. This helps researchers to develop a deeper understanding of the chemical behavior of pyrazole derivatives and their potential applications in various fields.
Used in Material Science:
In the field of material science, 3-METHYL-4-PHENYLPYRAZOLE can be used as a component in the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity. Its incorporation into these materials can lead to advancements in areas like catalysis, sensors, and energy storage.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 6001, 1988 DOI: 10.1016/S0040-4039(00)82251-0
Check Digit Verification of cas no
The CAS Registry Mumber 13788-84-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,8 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13788-84:
(7*1)+(6*3)+(5*7)+(4*8)+(3*8)+(2*8)+(1*4)=136
136 % 10 = 6
So 13788-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2/c1-8-10(7-11-12-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)
13788-84-6Relevant articles and documents
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Culp,F.B. et al.
, p. 2949 - 2953 (1973)
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Novel inhibitors of nicotinamide-n-methyltransferase for the treatment of metabolic disorders
Czech, Joerg,Dhakshinamoorthy, Saravanakumar,Hallur, Mahanandeesha S.,Kannt, Aimo,Kristam, Rajendra,Rajagopal, Sridharan,Ruf, Sven,Schreuder, Herman,Swamy, Indu,Zech, Gernot
supporting information, (2021/06/12)
Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expression in several cancer cell lines has been widely discussed in the literature, and recent work established a link between NNMT expression and metabolic diseases. Here we describe our approach to identify potent small molecule inhibitors of NNMT featuring different binding modes as elucidated by X-ray crystallographic studies.
Vilsmeier formylation of hydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones
Lebedev,Lebedeva,Sheludyakov,Kovaleva,Ustinova,Kozhevnikov
, p. 412 - 416 (2007/10/03)
Formylation of ten accessible phenylhydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones with the complex of POCl 3 with dimethylformamide was studied. Depending on the electronic and steric structure of the substrates, the reaction yields 1-phenyl- or 1-unsubstituted 3,4-dialkyl-, 3-alkyl-4-aryl-, or 3-alkyl-4-formylpyrazoles. These compounds can be readily oxidized into the corresponding carboxylic acids. 2005 Pleiades Publishing, Inc.
