13808-64-5 Usage
Description
4-Bromo-3-methylpyrazole is a white to cream-colored powder that serves as a versatile intermediate in chemical synthesis. It is a derivative of the pyrazole family, characterized by its bromine and methyl substituents, which contribute to its unique chemical properties and potential applications.
Uses
Used in Chemical Synthesis:
4-Bromo-3-methylpyrazole is used as a synthetic intermediate for the preparation of various chemical compounds. Its unique structure allows for further functionalization and incorporation into more complex molecules, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
4-Bromo-3-methylpyrazole is used as a key intermediate in the preparation of substituted piperidines. These substituted piperidines are potent, selective, and capable of penetrating the central nervous system (CNS). They act as α4β2 nicotinic acetylcholine receptor potentiators, which have potential therapeutic applications in the treatment of neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy.
Additionally, 4-Bromo-3-methylpyrazole is utilized in the synthesis of small molecular B2 receptor antagonists. These antagonists have potential applications in the treatment of various conditions, including inflammation, pain, and cardiovascular diseases, by blocking the action of certain receptors in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 13808-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,0 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13808-64:
(7*1)+(6*3)+(5*8)+(4*0)+(3*8)+(2*6)+(1*4)=105
105 % 10 = 5
So 13808-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H5BrN2/c1-3-4(5)2-6-7-3/h2H,1H3,(H,6,7)
13808-64-5Relevant articles and documents
Facile, fast and safe process development of nitration and bromination reactions using continuous flow reactors
Pelleter, Jacques,Renaud, Fabrice
, p. 698 - 705 (2009)
Chemists working in a pilot plant often face safety issues during scale-up operations. With the help of emerging microfluidic applications and microdevices, running hazardous, highly exothermic or potentially unstable reactions can be easily transposed into a safe continuous flow mode. This paper describes how a potentially hazardous pyrazole nitration and the bromination of a variety of electron-rich heteroaromatic substrates were efficiently performed using a cheap and easily available system for bench chemists. Advantages of the continuous flow mode in organic synthetic chemistry will be exemplified by the large-scale production of raw materials under safe, green and reproducible conditions.