149981-36-2Relevant articles and documents
Effect of Trifluoromethyl and Other Substituents on Activity of Xanthines at Adenosine Receptors
Jacobson, Kenneth A.,Shi, Dan,Gallo-Rodriguez, Carola,Manning, Malcolm,Mueller, Christa,et al.
, p. 2639 - 2644 (1993)
An aryl p-(trifluoromethyl) substituent increases the affinity of 1,3-disubstituted 8-phenylxanthines at A2a-adenosine receptors, while having little effect on affinity at A1-adenosine receptors.In contrast, an aryl p-(trifluoromethy