17863-69-3Relevant articles and documents
Short Communication. A potential chiral derivatizing agent for 1,2-diglycerides
Sonnet, Philip E.,Oliver, James E.,Waters, Roland M.,King, Gregory,Panicker, Sini
, p. 203 - 208 (1995)
Several chiral naphthylacetic acids have been prepared and evaluated as chiral derivatizing reagents for chiral alcohols.Fluorinated acids provide good general HPLC separations of chiral alcohols, especially 1,2-diglycerides.The separations and the 19F-NMR shift differences of pairs of diastereomers are documented. - Keywords: Chiral alcohols; 1,2-diglycerides; Fluoro-(1-naphthyl)acetic acids; Chiral derivatizing agents
Fosaprepitant derivative, synthesis thereof, and use thereof in long acting preparation
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, (2017/04/03)
The invention relates to a Fosaprepitant derivative, a synthesis thereof, and a use thereof in a long acting preparation. The invention relates to a compound of formula (I), and a salt, an N-oxide, a quaternary ammonium and a stereoisomer thereof. R to R in the formula (I) are as defined in claims. The invention also relates to an intermediate for preparing the compound of formula (I), and a method for preparing the compound of formula (I). The invention further relates to a use of the compound of formula (I) as a drug especially used for preventing chemotherapy induced acute and late nausea and vomiting.
Method for microwave synthesis of glyceryl caprylate-caprate
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Paragraph 0029-0032; 0034-0037; 0039-0041; 0043-0046; 0048, (2017/07/20)
The invention provides a preparation method for microwave synthesis of glyceryl caprylate-caprate. Caprylate-caprate and glycerin are reacted in the presence of a compound catalyst, and a glyceryl caprylate-caprate product is prepared by microwave synthesis. According to the method, the molar ratio of caprylate and caprate in the glyceryl caprylate-caprate is regulated, catalysis of the compound catalyst is combined, and a frequency band of 300 to 3,000MHz is adopted for microwave synthesis, so that the high-quality glyceryl caprylate-caprate of which the molar ratio of the caprylate and the caprate is controllable can be efficiently and rapidly prepared. According to the method, a high esterification rate can be achieved, and meanwhile, the energy consumption and the production cost of a reaction process can be remarkably reduced.
