1822-66-8Relevant articles and documents
Aminothiophene sulfonic acid ester
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Paragraph 0059; 0061, (2018/02/28)
PROBLEM TO BE SOLVED: To provide 3,4-disubstituted thiophene sulfonate usable as a monomer for a conductive polymer, and not having carboxylate on 2,5-positions, and to provide a method for producing the same.SOLUTION: This thiophene sulfonate is represented by general formula (1). The thiophene sulfonate is obtained, for example, by decarboxylation of 3,4-dihydroxy-2,5-dicarboxylic acid thiophene in a basic inert solvent, followed by reaction with sulfonyl chlorides in the presence of a tertiary alkylamine catalyst. (In the formula, Rand Reach independently represent a 1-8C alkyl, phenyl or tolyl).
Photo tuning of thiophene-2,5-dicarbohydrazide derivatives for their photoalignment ability-molecular modelling studies
Hegde, Gurumurthy,Murausky,Murauski,Kukhta,Adhikari,Komitov
, p. 79800 - 79806 (2015/10/05)
In this work, we reported a photoalignment of a nematic liquid crystal, promoted by thin alignment layers made from novel thiophene-2,5-dicarbohydrazide derivatives after being illuminated with linear polarized UV light. A clear indication of the relationship between the molecular structure and alignment properties of the materials was obtained by introducing a methyl substituent group (-CH3) in the molecular structure of some of the materials studied in this work. Interestingly, the illumination with linear polarized UV caused the preferred direction of liquid crystal alignment, promoted by these layers, to be oriented either parallel (in the case of the thiophene derivative without methyl substitution) or perpendicular (in the case of the thiophene derivative with methyl substitution). The mechanism behind the observed alignment effect is elucidated by molecular modelling studies. These studies suggested the change of the orientation of the molecular net dipole moment, when a methyl group is incorporated in the molecular structure of the materials, as a possible origin. Such information is indispensable for the design and synthesis of novel photo-alignment materials for liquid crystal displays of high quality.
Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene
Kulandasamy, Ravi,Adhikari, Airody Vasudeva,Stables, James P.
experimental part, p. 3672 - 3679 (2009/11/30)
A series of new 3,4-dipropyloxy-N2,N5-bis(substituted)thiophene-2,5-dicarbohydrazides (4-30) were synthesized from ethyl thiodiglycolate and diethyloxalate through multistep reactions. Following Dieckmann-Komppa reaction, the required precursor 3,4-dihydroxythiophene-2,5-diester (1) was prepared. This was derivatized with propyl bromide and further converted to corresponding hydrazide (3), which was finally transformed to targeted hydrazones (4-30) by conventional methods. The newly synthesized compounds were characterized using FT-IR, 1H and 13C NMR, EI-MS and elemental analyses. The anticonvulsant activity of all the title compounds was investigated against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scMET) models and their neurotoxicity was also evaluated. Some of the selected compounds were subjected to 6 Hz test in order to evaluate their uncover activities. Compound 3,4-dipropyloxy-N2,N5-bis[1-(2-thienyl)ethylidene]thiophene-2,5-dicarbohydrazide (15) has emerged as a lead in this series with less neurotoxicity.
