185057-53-8Relevant articles and documents
Recognition of mandelate stereoisomers by chiral porphyrin hosts: Prediction of stereopreference in guest binding a priori using a simple binding model?
Nandipati, Vijay,Akinapelli, Karthik,Koya, Lakshmi,Starnes, Stephen D.
supporting information, p. 985 - 991 (2015/02/05)
Rigid porphyrin hosts that mimic the spatial arrangement of mandelate recognition motifs lead to stereoselective receptors and illustrate how subtle structural differences in host design have significant impact on guest recognition. The porphyrin hosts are obtained with minimal synthetic effort from readily available chiral amine precursors and are modular in design. The chiral recognition properties of the porphyrin-based hosts with chiral carboxylate-containing guests and chiral amines are described. UV/vis and 1H NMR spectroscopic results indicate some of these porphyrin hosts undergo an induced fit conformational change upon guest binding.
Dipeptides which promote release of growth hormone
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, (2008/06/13)
Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis. STR1