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18527-19-0

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18527-19-0 Usage

Description

(4-Chlorophenylthio)acetonitrile, with the chemical formula C8H6ClNS, is a colorless to light yellow liquid characterized by a strong, pungent odor. It is a chemical intermediate that plays a significant role in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. This versatile building block is also utilized in the production of thiazole derivatives, which have a wide range of industrial applications. However, due to its hazardous nature, it requires careful handling to prevent irritation to the eyes, skin, and respiratory system, as well as potential long-term health effects.

Uses

Used in Pharmaceutical Industry:
(4-Chlorophenylthio)acetonitrile is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its ability to form diverse chemical structures makes it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, (4-Chlorophenylthio)acetonitrile serves as an intermediate in the production of various agrochemicals, such as pesticides and herbicides, to help protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
(4-Chlorophenylthio)acetonitrile is used as a versatile building block in organic synthesis, enabling the creation of a wide array of chemical structures for various applications across different industries.
Used in Thiazole Derivatives Production:
(4-Chlorophenylthio)acetonitrile is used as a reagent in the production of thiazole derivatives, which have diverse industrial applications, including in the development of dyes, pigments, and other specialty chemicals.
Safety Precautions:
Due to its hazardous nature, (4-Chlorophenylthio)acetonitrile should be handled with care to minimize the risk of irritation to the eyes, skin, and respiratory system. Proper safety measures, including the use of personal protective equipment and adherence to safety guidelines, are essential to prevent potential long-term health effects.

Check Digit Verification of cas no

The CAS Registry Mumber 18527-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18527-19:
(7*1)+(6*8)+(5*5)+(4*2)+(3*7)+(2*1)+(1*9)=120
120 % 10 = 0
So 18527-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClNS/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,6H2

18527-19-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Price
  • Detail
  • Alfa Aesar

  • (A12319)  (4-Chlorophenylthio)acetonitrile, 98%   

  • 18527-19-0

  • 1g

  • 97.0CNY

  • Detail
  • Alfa Aesar

  • (A12319)  (4-Chlorophenylthio)acetonitrile, 98%   

  • 18527-19-0

  • 5g

  • 391.0CNY

  • Detail
  • Alfa Aesar

  • (A12319)  (4-Chlorophenylthio)acetonitrile, 98%   

  • 18527-19-0

  • 25g

  • 1729.0CNY

  • Detail

18527-19-0Relevant articles and documents

Dealkylative intercepted rearrangement reactions of sulfur ylides

Empel, Claire,Hock, Katharina J.,Koenigs, Rene M.

supporting information, p. 338 - 341 (2019/01/09)

Sulfur ylides are well-known to undergo sigmatropic rearrangement reaction. Herein, we describe a novel reactivity of sulfur ylides, which provides access to the product of a formal functional group metathesis upon dealkylative interception of the rearrangement process. Using a simple iron catalyst and in situ generated diazoalkanes this method provides access to α-mercaptoacetonitrile derivatives.

Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis

G?tz, Kathrin H.,Hacker, Stephan M.,Mayer, Daniel,Dürig, Jan-Niklas,Stenger, Steffen,Marx, Andreas

, p. 2682 - 2689 (2017/10/27)

The intracellular concentration of diadenosine tetraphospate (Ap4A) increases upon exposure to stress conditions. Despite being discovered over 50 years ago, the cellular functions of Ap4A are still enigmatic. If and how the varied Ap4A is a signal and involved in the signaling pathways leading to an appropriate cellular response remain to be discovered. Because the turnover of Ap4A by Ap4A cleaving enzymes is rapid, small molecule inhibitors for these enzymes would provide tools for the more detailed study of the role of Ap4A. Here, we describe the development of a high-throughput screening assay based on a fluorogenic Ap4A substrate for the identification and optimization of small molecule inhibitors for Ap4A cleaving enzymes. As proof-of-concept we screened a library of over 42, 000 compounds toward their inhibitory activity against the Ap4A phosphorylase (Rv2613c) of Mycobacterium tuberculosis (Mtb). A sulfanylacrylonitril derivative with an IC50 of 260 ± 50 nM in vitro was identified. Multiple derivatives were synthesized to further optimize their properties with respect to their in vitro IC50 values and their cytotoxicity against human cells (HeLa). In addition, we selected two hits to study their antimycobacterial activity against virulent Mtb to show that they might be candidates for further development of antimycobacterial agents against multidrug-resistant Mtb.

Synthesis of organic sulfides via Zn/AlCl3 system in aqueous media

Lakouraj,Movassagh,Fadaei

, p. 1237 - 1242 (2007/10/03)

An efficient procedure for preparation of various sulfides has been introduced through a simple reaction of disulfides with suitable alkyl or aryl halides which is promoted by commercial zinc powder in the presence of AlCl3 in aqueous media at 65°C.

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