19490-00-7Relevant articles and documents
Continuous Flow Organocatalytic Chlorination of Alkenes
Gallos, John K.,Iordanidis, Nicolaos S.,Koftis, Theocharis V.,Stathakis, Christos I.,Zografos, Alexandros L.
supporting information, p. 5058 - 5062 (2021/09/28)
A regioselective anti-dichlorination and allylic chlorination of isolated double bonds is described. Such chlorination reactions benefit from a combination of methyl phenyl sulfoxide and TMSCl. The method has been appropriately adjusted to fit the continuous flow technology requirements, aiming to a broader industrial implementation for the synthesis of pharmaceutically important compounds. Towards the same direction, a catalytic protocol has been developed, using sub-stoichiometric amount of sulfoxide and environmentally friendly H2O2 as the stoichiometric oxidant, with comparable efficacy.