100394-04-5

Basic information

• Product Name: ethyl 2-acetoxy-2-cyano-2-phenylacetate
• Synonyms: ethyl 2-acetoxy-2-cyano-2-phenylacetate
• CAS NO: 100394-04-5
• Molecular Weight: 247.251
• Mol File: 100394-04-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-acetoxy-2-cyano-2-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-acetoxy-2-cyano-2-phenylacetate(100394-04-5)
• EPA Substance Registry System: ethyl 2-acetoxy-2-cyano-2-phenylacetate(100394-04-5)

Safety Data

• Hazardous Substances Data: 100394-04-5(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 631-57-2 Acetyl cyanide 
• 108-24-7 acetic anhydride 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 857211-72-4 α-Hydroxy-α-phenyl-β-(N-acetyl-amino)-propionsaeureaethylester 
• 120035-07-6 3-Amino-2-phenyl-propandiol-(1,2) 
• 135959-07-8 α-(aminomethyl)benzeneacetic acid,ethyl ester 
• 99986-48-8 ethyl 3-amino-2-hydroxy-2-phenylpropanoate 
• 98996-35-1 (+/-)-3-amino-2-hydroxy-2-phenylpropanoic acid 
• 4370-95-0 3-amino-2-phenyl-propionic acid 
• 62247-39-6 3-Hydroxy-2-phenyl-1-aminopropane 

Relevant articles and documents

N-Heterocyclic Carbene-Catalysed Direct Synthesis of Cyano Esters via Cyanation-Esterification Reaction of α-Keto Esters

The cyanation-esterification reaction of α-keto esters catalysed by N-heterocyclic carbenes (NHCs) is developed. Under the catalysis of 10 mol% 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, aromatic and aliphatic α-keto esters reacted with ethyl cyanoformate or acetyl cyanide to produce the corresponding cyano esters with a tetrasubstituted carbon center in high yields.