1011-15-0

Basic information

• Product Name: 1-(2-Fluorophenyl)piperazine
• Synonyms: RARECHEM AH CK 0103;AKOS BBS-00003615;1-(2-FLUOROPHENYL)PIPERAZINE;LABOTEST-BB LT00159366;2-(1-Piperazino)fluorobenzene;1-(2-Fluorophenyl)piperazine 97%;1-(2-Fluorophenyl)piperazine97%;1-(2-Fluorphenyl)-piperazine
• CAS NO: 1011-15-0
• Molecular Formula: C₁₀H₁₃FN₂
• Molecular Weight: 180.22
• EINECS: 213-780-4
• Product Categories: Piperaizine;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 1011-15-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 44-48℃
• Boiling Point: 150 °C3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.141 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0031mmHg at 25°C
• Refractive Index: n20/D 1.556(lit.)
• PKA: 8.78±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 611787
• CAS DataBase Reference: 1-(2-Fluorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Fluorophenyl)piperazine(1011-15-0)
• EPA Substance Registry System: 1-(2-Fluorophenyl)piperazine(1011-15-0)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-24/25
• RIDADR: 2923
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1011-15-0(Hazardous Substances Data)

Usage

Description

1-(2-Fluorophenyl)piperazine, with the CAS number 1011-15-0, is a chemical compound that is characterized as a clear colorless to light yellow liquid. It is primarily recognized for its utility in the field of organic synthesis, where it serves as a valuable building block for the creation of more complex molecules and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
1-(2-Fluorophenyl)piperazine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of drugs targeting specific receptors in the human body, potentially leading to the creation of novel medications for a range of health conditions.
Used in Chemical Research:
In the realm of chemical research, 1-(2-Fluorophenyl)piperazine is utilized as a research tool to study the properties and interactions of different molecules. Its clear colorless to light yellow liquid form makes it suitable for various experimental setups, contributing to the advancement of knowledge in organic chemistry and related fields.
Used in Organic Synthesis:
1-(2-Fluorophenyl)piperazine is used as a versatile building block in organic synthesis for the creation of a wide array of chemical compounds. Its fluorophenyl and piperazine moieties offer opportunities for further functionalization and modification, making it a valuable asset in the synthesis of complex organic molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C10H13FN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2/p+1

Upstream product

• 348-54-9 2-Fluoroaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 110-85-0 piperazine 
• 1072-85-1 o-fluorobromobenzene 
• 348-51-6 1-chloro-2-fluorobenzene 
• 367-11-3 ortho-difluorobenzene 

Downstream Products

• 57962-05-7 2-{2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-ethyl}-quinoline 
• 78069-76-8 1-(2-Fluoro-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine 
• 103378-45-6 N-(5H-Dibenzo[a,d]cyclohepten-5-yl)-4-[4-(2-fluoro-phenyl)-piperazin-1-yl]-butyramide 
• 103377-54-4 N-(5,11-Dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-4-[4-(2-fluoro-phenyl)-piperazin-1-yl]-butyramide 
• 103247-53-6 2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-acetamide 
• 127625-57-4 2-<3-<4-(2-fluorophenyl)-1-piperazinyl>propyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide 
• 139331-46-7 2-{3-[4-(2-fluorophenyl)-1-piperazinyl]propyl}-5-methyl-2H-1,4-benzothiazin-3(4H)-one.dihydrochloride 
• 103076-70-6 2-{2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-ethoxy}-benzaldehyde 
• 103076-85-3 2-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propoxy}-benzaldehyde 
• 83482-10-4 1-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-3-(3,7,7-trimethyl-5,9-dihydro-6,8-dioxa-2-aza-benzocyclohepten-4-yloxy)-propan-2-ol 
• 103072-95-3 2-(2-{2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-ethoxy}-phenyl)-thiazolidine-3-carboxylic acid methylamide 
• 103073-17-2 2-(2-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-thiazolidine-3-carboxylic acid methylamide 
• 77176-63-7 N-(2-Allyloxy-phenyl)-N-{3-[4-(2-fluoro-phenyl)-piperazin-1-yl]-2-hydroxy-propyl}-methanesulfonamide; hydrochloride 
• 77166-25-7 N-(2-Allyloxy-phenyl)-N-{3-[4-(2-fluoro-phenyl)-piperazin-1-yl]-2-hydroxy-propyl}-4-methyl-benzenesulfonamide; hydrochloride 

Relevant articles and documents

Evaluation of substituted n-phenylpiperazine analogs as D3 vs. D2 dopamine receptor subtype selective ligands

N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. The binding for a number of these receptor subtype selective compounds was found to be consistent with their ability to bind at the D3 dopamine receptor subtype in a bitopic manner. In this study, a series of the 3-thiophenephenyl and 4-thiazolylphenyl fluoride substituted N-phenylpiperazine analogs were evaluated. Compound 6a was found to bind at the human D3 receptor with nanomolar affinity with substantial D3 vs. D2 binding selectivity (approximately 500-fold). Compound 6a was also tested for activity in two in-vivo assays: (1) a hallucinogenic-dependent head twitch response inhibition assay using DBA/2J mice and (2) an L-dopa-dependent abnormal involuntary movement (AIM) inhibition assay using unilateral 6-hydroxydopamine lesioned (hemiparkinsonian) rats. Compound 6a was found to be active in both assays. This compound could lead to a better understanding of how a bitopic D3 dopamine receptor selective ligand might lead to the development of pharmacotherapeutics for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease.

7-benzyl-4-(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives and Composition for skin whitening and Pharmaceutical composition for use in preventing or treating disorders of Melanin Hyperpigmentation containing the same as an active ingredient

The present invention relates to a 7-benzyl-4(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivative, and to a composition for skin whitening, comprising the same as an active ingredient. Since the derivative exhibits the effect of inhibiting the production of melanin even when used in a small amount, it is useful as a pharmaceutical composition for preventing or treating melanin hyperpigmentation diseases, a cosmetic composition for skin whitening, and a health functional food for skin whitening.

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.