1012057-30-5

Basic information

• Product Name: 4-(3-ethynylphenylamino)quinazolin-6-yl acetate
• CAS NO: 1012057-30-5
• Molecular Weight: 303.32
• Mol File: 1012057-30-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(3-ethynylphenylamino)quinazolin-6-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-ethynylphenylamino)quinazolin-6-yl acetate(1012057-30-5)
• EPA Substance Registry System: 4-(3-ethynylphenylamino)quinazolin-6-yl acetate(1012057-30-5)

Safety Data

• Hazardous Substances Data: 1012057-30-5(Hazardous Substances Data)

Upstream product

• 179688-15-4 3,4-dihydro-4-oxoquinazolin-6-yl acetate 
• 16064-10-1 6-hydroxyquinazolin-4(3H)-one 
• 54060-30-9 3-acetylenephenylamine 
• 179246-11-8 4-chloroquinazoline-6-yl acetate 

Downstream Products

• 1012057-31-6 4-((3-ethynylphenyl)amino)quinazolin-6-ol 

Relevant articles and documents

TARTRATE SALTS OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to tartrate salts of quinazoline containing zinc-binding moiety based derivatives that are inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The tartrate salts may further act as HDAC inhibitors.

MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.