1012080-86-2

Basic information

• Product Name: 5',3'-bis-O-4,4'-dimethoxytrityl-2'-fluoro-2'-deoxyuridine
• Synonyms: 5',3'-bis-O-4,4'-dimethoxytrityl-2'-fluoro-2'-deoxyuridine
• CAS NO: 1012080-86-2
• Molecular Weight: 850.941
• Mol File: 1012080-86-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5',3'-bis-O-4,4'-dimethoxytrityl-2'-fluoro-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5',3'-bis-O-4,4'-dimethoxytrityl-2'-fluoro-2'-deoxyuridine(1012080-86-2)
• EPA Substance Registry System: 5',3'-bis-O-4,4'-dimethoxytrityl-2'-fluoro-2'-deoxyuridine(1012080-86-2)

Safety Data

• Hazardous Substances Data: 1012080-86-2(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 56287-17-3 2'-deoxy-2'-fluorouridine 
• 294677-07-9 3',5'-di-O-(4,4'-dimethoxytrityl)-1-β-D-arabinofuranosyluridine 

Downstream Products

• 56287-17-3 2'-deoxy-2'-fluorouridine 

Relevant articles and documents

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.