10136-57-9Relevant articles and documents
The Synthesis and Characterization of s-Triazine-Cored Tripodal Structure and Its Salen/Salophen-Bridged Fe/Cr(III) Capped Complexes
Karatas, Erhan,Ucan, Halil Ismet
, p. 692 - 698 (2017)
A novel Schiff base compound was synthesized, and its complexation properties with Fe(III) and Cr(III) were investigated. Tripodal ligand was synthesized by the reaction of s-triazine and 4-hydroxybenzaldehyde. Then a Schiff base involving 8-hydroxyquinoline was synthesized by the reaction of 5-aminomethyl-8-hydroxyquinoline (QN) and 2,4,6-tris(p-formylphenoxy)-1,3,5-triazine (TRIPOD) in methanol/chloroform media. The obtained Schiff base (QN-TRIPOD) was then reacted with four trinuclear Fe(III) and Cr(III) complexes including tetradentate Schiff bases N,N′-bis(salicylidene)ethylenediamine (salenH2)/bis(salicylidene)-o-phenylenediamine (SalophenH2). The synthesized ligand and complexes were characterized by means of elemental analysis carrying out1H NMR, FTIR spectroscopy, thermal analyses, and magnetic susceptibility measurements. Finally, metal ratios of the prepared complexes were determined by using atomic adsorption spectrometry.
Synthesis, characterization and application of uranyl ion imprinted polymers of aniline and 8-hydroxy quinoline functionalized aniline
Milja,Krupa,Rao
, p. 30718 - 30724 (2014)
In this work we report a simple method for the synthesis of uranyl ion imprinted and non imprinted polyaniline (IPAN and NIPAN) and a copolymer of 8-hydroxyquinoline functionalized aniline (ANHQ) and aniline (IFPAN and NIFPAN) using potassium dichromate and ammonium persulphate as the initiators. The structural characterization of the synthesized materials was done by FTIR and UV-Visible spectroscopy, morphology by SEM, thermal properties by TG and electrochemical properties by cyclic voltammetry. Application of the synthesized materials in removal of uranyl ion was studied using solid phase extraction (SPE). Various parameters were optimized to get quantitative removal from aqueous samples buffered to neutral pH using ammonium acetate. Selectivity and reusability studies were carried out to demonstrate the possible application in real sample analysis.
Influence of metal coordination on the mismatch tolerance of ligand-modified PNA duplexes
Watson, Richard M.,Skorik, Yury A.,Patra, Goutam K.,Achim, Catalina
, p. 14628 - 14639 (2005)
Recent studies on metal incorporation in ligand-modified nucleic acids have focused on the effect of metal coordination on the stability of metal-containing duplexes or triplexes and on the metal binding selectivity but did not address the effect of the sequence of the nucleic acid in which the ligands are incorporated. We have introduced 8-hydroxyquinoline Q in 10-mer PNA strands with various sequences and have investigated the properties of the duplexes formed from these strands upon binding of Cu2+. Variable-temperature UV-vis spectroscopy shows that, in the presence of Cu 2+, duplexes are formed even from ligand-modified Q-PNA strands that have a large number of mismatches. Spectrophotometric titrations demonstrate that at any temperature, one Cu2+ ion binds a pair of Q-PNA strands that each contain one 8-hydroxyquinoline, but below the melting temperature, the PNA duplex exerts a supramolecular chelate effect, which prevents the transformation in the presence of excess Cu2+ of the 1:2 Cu 2+:Q-PNA complexes into 1:1 complexes. EPR spectroscopy gives further support for the existence in the duplexes of [CuQ2] moieties that are similar to the corresponding square planar synthetic complex formed between Cu2+ and 8-hydroxyquinoline. As PNA duplexes show a preferred handedness due to the chiral induction effect of a C-terminal L-lysine, which is transmitted through stacking interactions within the duplex, only if the metal-containing duplex has complementary strands, does it show a chiral excess measured by CD spectroscopy. The strong effect of the metal-ligand moiety is suggestive of an increased correlation length in PNA duplexes that contain such moieties. These results indicate that strong metal-ligand alternative base pairs significantly diminish the importance of Watson-Crick base pairing for the formation of a stable PNA duplex and lead to high mismatch tolerance, a principle that can be used in the construction of hybrid inorganic-nucleic acid nanostructures.
Fluorescence-enhanced optical sensor for detection of Al3+ in water based on functionalised nanoporous silica type SBA-15
Karimi, Mehdi,Badieia, Alireza,Ziarani, Ghodsi Mohammadi
, p. 1431 - 1438 (2016)
An organic-inorganic hybrid optical sensor (PQ-SBA-15) was designed and prepared through functionalisation of the SBA-15 surface with 3-piperazinepropyltriethoxysilane followed by covalently attaching 8-hydroxyquinoline. Characterisation techniques, including FT-IR, thermal gravimetric, N2 adsorption-desorption and X-ray powder diffraction analyses, showed that the organic moieties were successfully grafted onto the surface of SBA-15 without the SBA-15 structure collapsing. The evaluation of the sensing ability of PQ-SBA-15 using fluorescence spectroscopy revealed that the PQ-SBA-15 was a selective fluorescence enhancement-based optical sensor for Al3+ in water in the presence of a wide range of metal cations including Na+, Mg2+, K+, Ca2+, Cr3+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+ and Pb2+ with a limit of detection of 8.8 × 10-7 M. In addition, good linearity was observed between the fluorescence intensity and the concentration of Al3+.
Compound for promoting cell movement, pharmaceutical composition as well as preparation and application of compound
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Paragraph 0016; 0033; 0035, (2021/07/10)
The invention belongs to the field of medicinal chemistry, and particularly relates to a compound for promoting cell movement, a pharmaceutical composition and preparation and application thereof. The compound provided by the invention is 5-(isobutoxymethyl) quinoline-8-alcohol or 5-(isobutoxymethyl) quinoline-8-alcohol hydrochloride, and tests prove that the compound can promote the movement of NIH/3T3 and inhibit the movement of nasopharyngeal carcinoma cells CNE2 at the same time, has good safety, has a remarkable healing effect on skin wounds of mice, and can be used for preparing drugs for treating the skin wounds of the mice. The compound can be applied to preparation of drugs for promoting wound healing, is especially suitable for surgical patients with tumor combined with diabetes, can accelerate wound healing of the patients without causing tumor cell diffusion, and has extremely high medicinal potential.
Identification of Quinolinols as Activators of TEAD-Dependent Transcription
Pobbati, Ajaybabu V.,Mejuch, Tom,Chakraborty, Sayan,Karatas, Hacer,Bharath, Sakshibeedu R.,Guéret, Stéphanie M.,Goy, Pierre-Alexis,Hahne, Gernot,Pahl, Axel,Sievers, Sonja,Guccione, Ernesto,Song, Haiwei,Waldmann, Herbert,Hong, Wanjin
, p. 2909 - 2921 (2019/12/24)
The transcriptional co-regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are the vertebrate downstream effectors of the Hippo signaling pathway that controls various physiological and pathological processes. YAP and TAZ pair with the TEAD (TEA domain) family of transcription factors to initiate transcription. We previously identified a tractable pocket in TEADs, which has been physiologically shown to bind palmitate. Herein, a TEAD-palmitate interaction screen was developed to select small molecules occupying the palmitate-binding pocket (PBP) of TEADs. We show that quinolinols were TEAD-binding compounds that augment YAP/TAZ-TEAD activity, which was verified using TEAD reporter assay, RT-qPCR, and RNA-Seq analyses. Structure-activity relationship investigations uncovered the quinolinol substituents that are necessary for TEAD activation. We reveal a novel mechanism where quinolinols stabilize YAP/TAZ protein levels by occupying the PBP. The enhancement of YAP activity by quinolinols accelerates the in vivo wound closure in a mouse wound-healing model. Although small molecules that occupy the PBP have been shown to inhibit YAP/TAZ-TEAD activity, leveraging PBP to activate TEADs is a novel approach.
