101460-34-8

Basic information

• Product Name: (S)-(-)-2-Amino-3-bromo-N-[(1-ethyl-2-pyrrolidin- yl)methyl]-5,6-dimethoxybenzamide
• Synonyms: NCQ-318
• CAS NO: 101460-34-8
• Molecular Formula: C₁₆H₂₄BrN₃O₃
• Molecular Weight: 386.29198
• Mol File: 101460-34-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-(-)-2-Amino-3-bromo-N-[(1-ethyl-2-pyrrolidin- yl)methyl]-5,6-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-Amino-3-bromo-N-[(1-ethyl-2-pyrrolidin- yl)methyl]-5,6-dimethoxybenzamide(101460-34-8)
• EPA Substance Registry System: (S)-(-)-2-Amino-3-bromo-N-[(1-ethyl-2-pyrrolidin- yl)methyl]-5,6-dimethoxybenzamide(101460-34-8)

Safety Data

• Hazardous Substances Data: 101460-34-8(Hazardous Substances Data)

Upstream product

• 101460-35-9 3-bromo-5,6-dimethoxyanthranilic acid 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 541-41-3 chloroformic acid ethyl ester 
• 122744-80-3 6-bromo-2-carboxy-3,4-dimethoxy-N-(tert-butoxycarbonyl)aniline 
• 102421-43-2 N-((1,1-dimethylethyl)oxycarbonyl)-3,4-dimethoxyaniline 
• 106107-48-6 6-((tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid 
• 107188-81-8 (-)-(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2,3-dimethoxybenzamide 
• 122744-79-0 (S)-6-amino-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide 

Relevant articles and documents

OXYSALICYLAMIDO DERIVATIVES

Novel therapeutically active compounds of the formula STR1 wherein Z i, being Z 1, Z 2 or Z 3, is the same or different and selected among OH, OR 1, NH 2, NR 2 4, NHR. sup.4, SH, SR. sup.4 and OR 4 wherein R 1 is a formyl group, an acyl group, an alkoxycarbonyl group or a mono-or dialkylcarbamoyl group and R 4 is a lower alkyl group,R 2 is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group,R 3 is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, meta or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z 1, Z. sup.2 and Z 3 is a group OR 4 and further provided that when Z. sup.2 is OH or NH 2, Z 1 is NR. sub.2 4, NHR 4, SH, SR 4 or OR 4 or a physiologically acceptable salt or optical isomer thereof, intermediates and methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.

Secondary β-Aminobenzamide and Heteroatom Directed Lithiation in the Synthesis of 5,6-Dimethoxyanthanilamides and Related Compounds

Directed ortho-lithiation strategies have been applied in the synthesis of the dopamine D-2 antagonist (S)-6-amino-5-bromo-2,3-dimethoxy-N-benzamide (NCQ 318).The secondary β-amino side chain was found to be a powerful orth