101460-68-8Relevant articles and documents
OXYSALICYLAMIDO DERIVATIVES
-
, (2008/06/13)
Novel therapeutically active compounds of the formula STR1 wherein Z i, being Z 1, Z 2 or Z 3, is the same or different and selected among OH, OR 1, NH 2, NR 2 4, NHR. sup.4, SH, SR. sup.4 and OR 4 wherein R 1 is a formyl group, an acyl group, an alkoxycarbonyl group or a mono-or dialkylcarbamoyl group and R 4 is a lower alkyl group,R 2 is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group,R 3 is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, meta or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z 1, Z. sup.2 and Z 3 is a group OR 4 and further provided that when Z. sup.2 is OH or NH 2, Z 1 is NR. sub.2 4, NHR 4, SH, SR 4 or OR 4 or a physiologically acceptable salt or optical isomer thereof, intermediates and methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.
Potential Antipsychotic Agents. 5. Synthesis and Antidopaminergic Properties of Substituted 5,6-Dimethoxysalicylamides and Related Compounds
Hoegberg, Thomas,Bengtsson, Stefan,Paulis, Tomas de,Johansson, Lars,Stroem, Peter,et al.
, p. 1155 - 1163 (2007/10/02)
A series of 3-substituted 5,6-dimethoxysalicylamides III (9-13 and 15) has been synthesized from the corresponding 2,5,6-trimethoxybenzoic acids.Relaxation times T1 and carbon chemical shifts of the methoxy groups in III showed that the 6-metho
