1018349-44-4

Basic information

• Product Name: 3-(4-bromo-benzyloxy)-2-methyl-propionic acid methyl ester
• Synonyms: 3-(4-bromo-benzyloxy)-2-methyl-propionic acid methyl ester
• CAS NO: 1018349-44-4
• Molecular Weight: 287.153
• Mol File: 1018349-44-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-bromo-benzyloxy)-2-methyl-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromo-benzyloxy)-2-methyl-propionic acid methyl ester(1018349-44-4)
• EPA Substance Registry System: 3-(4-bromo-benzyloxy)-2-methyl-propionic acid methyl ester(1018349-44-4)

Safety Data

• Hazardous Substances Data: 1018349-44-4(Hazardous Substances Data)

Upstream product

• 1018349-36-4 2-(4-bromo-benzyloxy)-1-methylpyridinium triflate 
• 72657-23-9 methyl (R)-3-hydroxy-2-methylpropionate 
• 146285-52-1 (4-bromobenzyl)-2,2,2-trichloroacetimidate 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 1147886-64-3 (S)-3-(4-bromo-benzyloxy)-2-methyl-propan-1-ol 
• 1247088-34-1 C₃₄H₄₄N₂O₄ 
• 1006865-32-2 1-bromo-4-((S)-3-methoxy-2-methyl-propoxymethyl)-benzene 
• 1366039-59-9 C₃₉H₅₂N₂O₆ 

Relevant articles and documents

Preparation of Alkyl Ethers with Diallyltriazinedione-Type Alkylating Agents (ATTACKs-R) Under Acid Catalysis

Diallyltriazinedione-type acid-catalyzed alkylating agents (ATTACKs-R) with 10 different alkyl groups (R), including benzyl, substituted benzyl, allyl, and methyl groups were synthesized. The palladium-catalyzed intramolecular O-to-N allylic rearrangement of 2,4-bis(allyloxy)-6-chloro-1,3,5-triazine was developed to introduce various alkoxy groups into the N,N′-dialkylated triazinedione skeleton. O-Alkylation of alcohols with ATTACKs-R was carried out in 1,4-dioxane in the presence of 2,6-di-tert-butylpyridinium trifluoromethanesulfonate or trifluoromethanesulfonic acid as a catalyst. Six selected ATTACKs-R bearing benzylic R groups were employed to prepare alkyl ethers from primary, secondary, and tertiary alcohols. The reactions of ATTACKs-R bearing an o-nitro-substituted benzyl group tended to afford low yields. Comparison of four different triazinedione-based benzylating reagents suggested that the N,N′-substituents affected the reactivity.

4,4-DISUBSTITUTED PIPERIDINES

The application relates to 4,4-disubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R2, has the meanings explained in the description, a process for their preparation