1018901-77-3Relevant articles and documents
Highly efficient amine organocatalysts based on bispidine for the asymmetric Michael addition of ketones to nitroolefins
Yang, Zhigang,Liu, Jie,Liu, Xiaohua,Wang, Zhen,Feng, Xiaoming,Su, Zhishan,Hua, Changwei
supporting information; experimental part, p. 2001 - 2006 (2009/08/14)
A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Additionally, a theoretical study of transition structures revealed that this bispidinebased primary-secondary amine catalyst could serve through an enamine intermediate and H-bond interaction, which was important for the reactivity and selectivity of this reaction.