1026131-79-2

Basic information

• Product Name: 2,2-Dimethyl-propionic acid 2-nitro-3-((E)-2-pyrrolidin-1-yl-vinyl)-benzyl ester
• CAS NO: 1026131-79-2
• Molecular Weight: 332.4
• Mol File: 1026131-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-Dimethyl-propionic acid 2-nitro-3-((E)-2-pyrrolidin-1-yl-vinyl)-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-propionic acid 2-nitro-3-((E)-2-pyrrolidin-1-yl-vinyl)-benzyl ester(1026131-79-2)
• EPA Substance Registry System: 2,2-Dimethyl-propionic acid 2-nitro-3-((E)-2-pyrrolidin-1-yl-vinyl)-benzyl ester(1026131-79-2)

Safety Data

• Hazardous Substances Data: 1026131-79-2(Hazardous Substances Data)

Upstream product

• 18710-86-6 2-(3-methyl-2-nitrophenyl)acetic acid 
• 80866-76-8 2-methyl-6-hydroxymethyl-1-nitrobenzene 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1074-88-0 1H-indole-7-carbaldehyde 
• 1074-87-9 indole-7-methanol 

Relevant articles and documents

Simple synthesis of 7-formyl-indole

A simple route to 7-formyl-indole (5) is described in which appropriately functionalized o-nitrotoluenes (1) are converted to 7-hydroxymethyl-indole (4) using the Batcho-Leimgruber process. Condensation of 3-methyl-2-nitrobenzyl alcohol (1a) with N,N-dimethylformamide dimethyl acetal yields the enamine 2a, which upon catalytic hydrogenation affords 4 in 22% yield. When the hydroxyl function in 1 is protected with pivaloyl or tetrahydropyranyl group, the yields of 4 are increased to 39% and 48%, respectively. Finally, 4 is oxidized with pyridinium chlorochromate (PCC) to afford 5 in 86% yield. Copyright Taylor & Francis Group, LLC.