1027-41-4

Basic information

• Product Name: ethyl 2,4-dioxo-6-phenylhex-5-enoate
• CAS NO: 1027-41-4
• Molecular Formula: C₁₄H₁₄O₄
• Molecular Weight: 246.2586
• Mol File: 1027-41-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 388.7°C at 760 mmHg
• Flash Point: 172.6°C
• Density: 1.168g/cm³
• Vapor Pressure: 3E-06mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: ethyl 2,4-dioxo-6-phenylhex-5-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,4-dioxo-6-phenylhex-5-enoate(1027-41-4)
• EPA Substance Registry System: ethyl 2,4-dioxo-6-phenylhex-5-enoate(1027-41-4)

Safety Data

• Hazardous Substances Data: 1027-41-4(Hazardous Substances Data)

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1896-62-4 (E)-benzalacetone 
• 85763-14-0 (E)-2,4-Dioxo-6-phenyl-hex-5-enoic acid 
• 141-52-6 sodium ethanolate 

Downstream Products

• 57409-49-1 methyl (E)-6-phenyl-2,4-dioxohex-5-enoate 
• 40753-30-8 5-styryl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester 
• 100884-20-6 2,4-dioxo-6-phenyl-hexanoic acid ethyl ester 
• 1154-90-1 Ethyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 102467-68-5 1,5-bis-(4-bromo-phenyl)-3-trans-cinnamoyl-formazan 
• 109866-41-3 1-phenyl-5-trans-styryl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 39088-76-1 5-trans-styryl-isoxazole-3-carboxylic acid methyl ester 
• 39088-85-2 5-[(E)-2-phenylethenyl]-3-isoxazolecarboxylic acid ethyl ester 
• 85814-93-3 4-hydroxy-6-phenylpyridine-2-carboxamide 
• 78296-37-4 4-hydroxy-6-phenylpyridine-2-carboxylic acid 
• 57050-20-1 4-oxo-6-phenyl-4H-pyran-2-carboxamide 
• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 1083-01-8 4-oxo-6-phenyl-4H-pyrane-2-carboxylic acid 
• 1241726-45-3 3-(1,5-diphenyl-1H-pyrazol-3-yl)-1H-indole-2-carboxylic acid 

Relevant articles and documents

Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines

Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described hereia These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.