103146-26-5

Basic information

• Product Name: 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide
• Synonyms: 4-[(4-DIMETHYLAMINO)-1-(4-FLUORO PHENYL)-1-HYDROXYBUTYL]-3-HYDROXY-METHYL BENZONITRILE HYDROBROMIDE;4-[4-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-1-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITRILE, MONOHYDROBROMIDE;4-[4-(Dimethylamino)-1-(4-Fluorophenyl)-1-HydroxyButyl]-3-(Hydroxymethyl)-Benzon;Benzonitrile, 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-, monohydrobromide;4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromid;Citadiol HBr;4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide###4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile;4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobro
• CAS NO: 103146-26-5
• Molecular Formula: BrH*C₂₀H₂₃FN₂O₂
• Molecular Weight: 423.32
• EINECS: 1592732-453-0
• Product Categories: API intermediates
• Mol File: 103146-26-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 201-205 °C(lit.)
• Boiling Point: 561.6 °C at 760 mmHg
• Flash Point: 293.5 °C
• Appearance: White solid
• Vapor Pressure: 1.89E-13mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide(103146-26-5)
• EPA Substance Registry System: 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide(103146-26-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 103146-26-5(Hazardous Substances Data)

Usage

Uses

Citadiol Hydrobromide is a precursor of Citalopram (C505000), an antidepressant.

InChI:InChI=1/C20H23FN2O2.BrH/c1-23(2)11-3-10-20(25,17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24;/h4-9,12,24-25H,3,10-11,14H2,1-2H3;1H

Upstream product

• 103146-25-4 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 
• 19070-16-7 3-(N,N-dimethylamino)propylmagnesium chloride 
• 352-13-6 4-flourophenylmagnesium bromide 
• 82104-74-3 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 109-54-6 3-(Dimethylamino)propyl chloride 

Downstream Products

• 59729-32-7 citalopram hydrobromide 
• 128173-53-5 4-(1S)-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile (+)-di-(p-toluoyl)tartaric acid 
• 128196-01-0 escitalopram 
• 219861-08-2 escitalopram oxalate 
• 103146-25-4 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 

Relevant articles and documents

METHOD OF PRODUCING CITALOPRAM DIOL COMPOUND

PROBLEM TO BE SOLVED: To provide a method of producing citalopram diol in a high purity and a high yield. SOLUTION: A production method for obtaining 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile by reacting 5-cyanophtalide with 4-magnesiumbromidefluorobenzene and 3-magnesiumchloride-N,N-dimethyl-1-propaneamine includes: a process of obtaining a solution of 4-magnesiumbromidefluorobenzene using less than 1 mol of magnesium to 1 mol of 4-bromofluorobenzene in an organic solvent; and a process of reacting less than 1 mol magnesium with 1 mol of 3-chloro-N,N-dimethyl-1-propanamine in an organic solvent to obtain a solution of 3-magnesiumchloride-N,N-dimethyl-1-propaneamine. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Preparation method of citalopram intermediate

The invention provides a preparation method of a citalopram intermediate, and belongs to the technical field of pharmaceuticals. In the method, 2-methyltetrahydrofuran is taken as a reaction solvent. Under the protection of nitrogen, a 4-fluorophenylmagnesium bromide solution Grignard reagent, 5-cyanophthalein and a N,N-dimethylpropyl magnesium chloride Grignard reagent are taken as raw materials. A reaction is carried out to synthesize 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrilehydrobromide. The method is characterized by high yield and high purity, and is suitable for industrial production.