10340-91-7Relevant articles and documents
Weber,Gokel
, p. 1637 (1972)
Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
Abdelraheem, Eman M. M.,Madhavachary, Rudrakshula,Rossetti, Arianna,Kurpiewska, Katarzyna,Kalinowska-Tlu?cik, Justyna,Shaabani, Shabnam,D?mling, Alexander
, p. 6176 - 6179 (2017)
An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8-11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope.
Electrochemical generation of alkyl and aryl isocyanides
Guirado, Antonio,Zapata, Andres,Gomez, Jesus L.,Trabalon, Luis,Galvez, Jesus
, p. 9631 - 9640 (1999)
An efficient and widely applicable reagent-free method for the synthesis of alkyl and aryl isocyanides has been established. The electrochemical reduction of alkyl and aryl carbonimidoyl dichlorides under constant cathode potential leads to the corresponding isocyanides in almost quantitative yields. The availability of the starting materials, the mildness of the reaction conditions as well as the easy isolation of products are noteworthy, advantageous features of the procedure.
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Echigo,Y. et al.
, p. 697 - 698 (1977)
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Multicomponent Ugi Reaction of Indole- N-carboxylic Acids: Expeditious Access to Indole Carboxamide Amino Amides
Zeng, Linwei,Sajiki, Hironao,Cui, Sunliang
, p. 5269 - 5272 (2019)
A novel multicomponent Ugi-type reaction for the synthesis of indole carboxamide amino amides from aldehydes, amines, isocyanides, and indole-N-carboxylic acids, which were simply prepared from indoles and CO2, is described. This method provides an expeditious and practical access to indole tethered peptide units, along with the achievement of remarkable structural diversity and brevity. Gram-scale reaction was conducted to demonstrate the scalability, and the products could be transformed to new indole derivatives.
Microwave-assisted synthesis of isonitriles: A general simple methodology
Porcheddu, Andrea,Giacomelli, Giampaolo,Salaris, Margherita
, p. 2361 - 2363 (2005)
(Chemical Equation Presented) A facile conversion of formamides to isonitriles under very mild conditions and microwave irradiation is described. This simple and efficient method has been applied for the synthesis of both aliphatic and aromatic isonitriles in high yields.
Method for preparing isonitrile compound
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Paragraph 0056-0061, (2021/01/30)
The invention discloses a method for preparing an isonitrile compound, and belongs to the field of organic synthesis. According to the method, sodium chlorodifluoroacetate or potassium bromodifluoroacetate is used as a difluoromethyl source and is condensed with primary amine under the action of alkali to obtain an isocyanide target product, so that isocyanide is generated in situ on the primary amine. The reaction raw materials, alkali and solvent used in the method are simple and easy to obtain, wide in source and convenient to operate, do not need special storage and use conditions, the method has the advantages of safety, low cost, high yield, simple process, environmental friendliness and the like, and has important application value in the fields of medicine, protein and polypeptidepreparation, pesticides, high polymer materials, dyes and the like.