1035374-20-9

Basic information

• Product Name: 3-Aminocyclobutanone hydrochloride
• Synonyms: 3-Aminocyclobutanone hydrochloride;3-aminocyclobutanone hydr...;3-AMinocyclobutanone HCl;Cyclobutanone, 3-amino-, hydrochloride;3-aminocyclobutan-1-one hydrochloride
• CAS NO: 1035374-20-9
• Molecular Formula: C₄H₇NO*ClH
• Molecular Weight: 122
• Mol File: 1035374-20-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 127-130 °C (decomp)
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Aminocyclobutanone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminocyclobutanone hydrochloride(1035374-20-9)
• EPA Substance Registry System: 3-Aminocyclobutanone hydrochloride(1035374-20-9)

Safety Data

• Hazardous Substances Data: 1035374-20-9(Hazardous Substances Data)

Usage

Uses

3-Aminocyclobutanone is used to prepare aminocyclopentenyl- and aminocyclobutylphosphinic acids as γ-aminobutyric acid ρ1 receptor antagonists. It is also used to prepare pyrrolopyrazine derivs. as selective spleen tyrosine kinase inhibitors.

InChI:InChI=1S/C4H7NO.ClH/c5-3-1-4(6)2-3;/h3H,1-2,5H2;1H

Upstream product

• 130233-77-1 3-oxocyclobutane-1-carbonyl chloride 
• 154748-49-9 3-(tert-butyloxycarbonylamino)cyclobutan-1-one 

Downstream Products

• 154748-49-9 3-(tert-butyloxycarbonylamino)cyclobutan-1-one 
• 1449278-40-3 tert-butyl (7-(3-fluorophenyl)-4-((3-oxocyclobutyl)carbamoyl)isoquinolin-1-yl)carbamate 

Relevant articles and documents

Truce–Smiles Rearrangements by Strain Release: Harnessing Primary Alkyl Radicals for Metal-Free Arylation

The ring-opening of 3-aminocyclobutanone oximes enables easy generation of primary alkyl radicals, capable of undergoing an unprecedented strain-release, desulfonylative radical Truce–Smiles rearrangement, providing divergent access to valuable 1,3 diamin

ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES

The invention provides novel compounds having the general formula(I) wherein A, R1 and R2 are as described herein, compositions including the compounds and use of the compounds for inhibiting angiogenesis by inhibition of MAP4K4.