103626-26-2 Usage
Description
N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine is a selective adenosine A1-R agonist, which is a type of compound that can selectively bind to and activate the adenosine A1 receptor. This property makes it a potential candidate for the development of treatments for various conditions.
Uses
Used in Pharmaceutical Industry:
N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine is used as a selective adenosine A1-R agonist for the development of treatments for neuropathic pain symptoms. Its ability to selectively activate the adenosine A1 receptor may provide a targeted approach to managing neuropathic pain, offering a potential alternative to conventional pain management therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 103626-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,6,2 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 103626-26:
(8*1)+(7*0)+(6*3)+(5*6)+(4*2)+(3*6)+(2*2)+(1*6)=92
92 % 10 = 2
So 103626-26-2 is a valid CAS Registry Number.
103626-26-2Relevant articles and documents
N6-substituted C5′-modified adenosines as A1 adenosine receptor agonists
Ashton,Baker, Stephen P.,Hutchinson, Sally A.,Scammells, Peter J.
, p. 1861 - 1873 (2008)
Adenosines bearing 5′-modification in conjunction with an N6-substituent have previously been shown to act as partial agonists at the A1 adenosine receptor. Our current work investigates the effect of modifying the 5′-position in conjunction with efficacious bicyclic and tricyclic N6-substituents. Several highly potent agonists for the A1 adenosine receptor were identified; however, all of these compounds behaved as full agonists. In keeping with previous reports, 5′-halogen and 5′-sulfide derivatives of N6-(endo-norborn-2-yl)adenosine were, in general, low nanomolar agonists of the A1 adenosine receptor. The known partial agonist, N6-cyclopentyl-5′-deoxy-5′-ethylthioadenosine (2), also behaved as a full agonist in our assay.
